Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.
Antibodies, Bispecific
/ genetics
Child
Humans
Leukemia, B-Cell
/ genetics
Leukemia, Lymphocytic, Chronic, B-Cell
/ genetics
Leukemia, Myeloid, Acute
/ genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
Transcription Factors
/ genetics
Translocation, Genetic
acute lymphoblastic leukemia
blinatumomab
lineage switch
minimal residual disease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Apr 2022
05 Apr 2022
Historique:
received:
25
02
2022
revised:
24
03
2022
accepted:
02
04
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
We report incidence and deep molecular characteristics of lineage switch in 182 pediatric patients affected by B-cell precursor acute lymphoblastic leukemia (BCP-ALL), who were treated with blinatumomab. We documented six cases of lineage switch that occurred after or during blinatumomab exposure. Therefore, lineage conversion was found in 17.4% of all resistance cases (4/27) and 3.2% of relapses (2/63). Half of patients switched completely from BCP-ALL to CD19-negative acute myeloid leukemia, others retained CD19-positive B-blasts and acquired an additional CD19-negative blast population: myeloid or unclassifiable. Five patients had
Identifiants
pubmed: 35409391
pii: ijms23074019
doi: 10.3390/ijms23074019
pmc: PMC8999738
pii:
doi:
Substances chimiques
Antibodies, Bispecific
0
Transcription Factors
0
blinatumomab
4FR53SIF3A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 17-29-06052
Organisme : Russian Foundation for Basic Research
ID : 18-29-09132
Organisme : Presidential grant
ID : 075-15-2020-338
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