The use of anticholinergic medication is associated with an increased risk of stroke-associated pneumonia.
Anticholinergic
Drugs
Pneumonia
Stroke
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
02
02
2022
accepted:
20
03
2022
pubmed:
14
4
2022
medline:
19
7
2022
entrez:
13
4
2022
Statut:
ppublish
Résumé
Pneumonia is a frequent medical complication after stroke. A few studies showed that the use of anticholinergic medication is associated with a higher risk of community acquired pneumonia in the elderly. We aimed to determine if there is any association between anticholinergic medication used before stroke and stroke-associated pneumonia (SAP). We analysed prospectively collected data of 675 patients with acute stroke (mean age 71.4 ± 13.3; 53.1% female). We used the Anticholinergic Drug Scale to assess anticholinergic exposure during a month preceding stroke onset. We diagnosed SAP in 14.7% of patients. The use of anticholinergic medication was associated with an elevated risk of SAP (OR 2.56, 95% CI 1.59-4.11, P < 0.01) in univariate analysis. This association remained significant in multivariable analysis adjusted for age, stroke severity, atrial fibrillation, previous myocardial infarction and respiratory tract diseases (OR 2.06, 95% CI 1.01-4.22, P = 0.04). The use of anticholinergic medication before stroke is associated with an increased risk of SAP.
Sections du résumé
BACKGROUND
BACKGROUND
Pneumonia is a frequent medical complication after stroke. A few studies showed that the use of anticholinergic medication is associated with a higher risk of community acquired pneumonia in the elderly. We aimed to determine if there is any association between anticholinergic medication used before stroke and stroke-associated pneumonia (SAP).
METHODS
METHODS
We analysed prospectively collected data of 675 patients with acute stroke (mean age 71.4 ± 13.3; 53.1% female). We used the Anticholinergic Drug Scale to assess anticholinergic exposure during a month preceding stroke onset.
RESULTS
RESULTS
We diagnosed SAP in 14.7% of patients. The use of anticholinergic medication was associated with an elevated risk of SAP (OR 2.56, 95% CI 1.59-4.11, P < 0.01) in univariate analysis. This association remained significant in multivariable analysis adjusted for age, stroke severity, atrial fibrillation, previous myocardial infarction and respiratory tract diseases (OR 2.06, 95% CI 1.01-4.22, P = 0.04).
CONCLUSIONS
CONCLUSIONS
The use of anticholinergic medication before stroke is associated with an increased risk of SAP.
Identifiants
pubmed: 35416612
doi: 10.1007/s40520-022-02123-x
pii: 10.1007/s40520-022-02123-x
doi:
Substances chimiques
Cholinergic Antagonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1935-1938Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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