The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway.
cardioprotective agent
mediators of inflammation
oxidative stress injury
perindopril
sepsis syndrome
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
21
01
2022
received:
08
10
2021
accepted:
01
04
2022
pubmed:
14
4
2022
medline:
17
8
2022
entrez:
13
4
2022
Statut:
ppublish
Résumé
Mortality rates associated with myocardial dysfunction due to sepsis and septic shock are generally high across the world. The present study focused on the antioxidant and anti-inflammatory effects of perindopril (PER) for the purpose of preventing the adverse effects of sepsis on the myocardium and developing new alternatives in treatment. The control group received only saline solution via the oral route for 4 days. The second group underwent cecal ligation puncture (CLP), and the third underwent CLP and received PER (2 mg/kg). Rats in the third group received 2 mg/kg PER per oral (p.o.) from 4 days before induction of sepsis. Thiobarbituric acid reactive species (TBARS), total thiol (-SH), interleukin-1 beta (IL-1β), IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and nuclear factor kappa B (NF-κB/p65) levels increased in the CLP groups. In contrast, PER (2 mg/kg) decreased the levels of biochemical parameters other than total-SH and decreased 8-OHdG, NF-κB/p65 immunopositivity in rat heart tissues. The data from this study show that impairment of the oxidant/antioxidant balance and inflammatory cytokine levels in favor of inflammation in heart tissue under septic conditions results in severe tissue damage. PER administration before sepsis was shown to exhibit antioxidant and anti-inflammatory properties by reducing these effects. This in turn increased the importance of PER as new evidence of its protective effects in heart tissue.
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
NF-kappa B
0
Tumor Necrosis Factor-alpha
0
Oxygen
S88TT14065
Perindopril
Y5GMK36KGY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23080Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
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