Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.
Compulsive behavior
Diffusion magnetic resonance imaging
Frontostriatal circuitry
Functional magnetic resonance imaging
NMDA antagonist
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
05
08
2021
accepted:
04
04
2022
pubmed:
15
4
2022
medline:
22
7
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compulsivity. Juvenile Sprague-Dawley rats received repeated quinpirole, resulting in compulsive checking behavior (n = 32; compulsive) or saline injections (n = 32; control). Eight compulsive and control rats received chronic memantine treatment, and eight compulsive and control rats received saline treatment for seven consecutive days between the 10th and 12th quinpirole/saline injection. Compulsive checking behavior was assessed, and structural and functional brain connectivity was measured with diffusion MRI and resting-state fMRI before and after treatment. The other rats received an acute single memantine (compulsive: n = 12; control: n = 12) or saline injection (compulsive: n = 4; control: n = 4) during pharmacological MRI after the 12th quinpirole/saline injection. An additional group of rats received a single memantine injection after a single quinpirole injection (n = 8). Memantine treatment did not affect compulsive checking nor frontostriatal structural and functional connectivity in the quinpirole-induced adolescent rat model. While memantine activated the frontal cortex in control rats, no significant activation responses were measured after single or repeated quinpirole injections. The lack of a memantine treatment effect in quinpirole-induced compulsive adolescent rats may be partly explained by the interaction between glutamatergic and dopaminergic receptors in the brain, which can be evaluated with functional MRI.
Identifiants
pubmed: 35419637
doi: 10.1007/s00213-022-06139-z
pii: 10.1007/s00213-022-06139-z
pmc: PMC9293859
doi:
Substances chimiques
Dopamine Agonists
0
Quinpirole
20OP60125T
Memantine
W8O17SJF3T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2457-2470Subventions
Organisme : nederlandse organisatie voor wetenschappelijk onderzoek
ID : NWO-VICI 016.130.663
Organisme : nederlandse organisatie voor wetenschappelijk onderzoek
ID : NWO-VENI 016.168.038
Organisme : hersenstichting
ID : F2014(1)-06
Organisme : fp7 ideas: european research council
ID : TACTICS no. 278948
Investigateurs
Jan Buitelaar
(J)
Saskia de Ruiter
(S)
Jilly Naaijen
(J)
Sophie Akkermans
(S)
Maarten Mennes
(M)
Marcel Zwiers
(M)
Shahrzad Ilbegi
(S)
Leonie Hennissen
(L)
Jeffrey Glennon
(J)
Ilse van de Vondervoort
(I)
Katarzyna Kapusta
(K)
Natalia Bielczyk
(N)
Houshang Amiri
(H)
Martha Havenith
(M)
Barbara Franke
(B)
Geert Poelmans
(G)
Janita Bralten
(J)
Tom Heskes
(T)
Elena Sokolova
(E)
Perry Groot
(P)
Steven Williams
(S)
Declan Murphy
(D)
David Lythgoe
(D)
Muriel Bruchhage
(M)
Iulia Dud
(I)
Bogdan Voinescu
(B)
Ralf Dittmann
(R)
Tobias Banaschewski
(T)
Daniel Brandeis
(D)
Konstantin Mechler
(K)
Ruth Berg
(R)
Isabella Wolf
(I)
Alexander Häge
(A)
Michael Landauer
(M)
Sarah Hohmann
(S)
Regina Boecker-Schlier
(R)
Matthias Ruff
(M)
Rick Dijkhuizen
(R)
Erwin Blezer
(E)
Milou Straathof
(M)
Kajo van der Marel
(K)
Pim Pullens
(P)
Wouter Mol
(W)
Annette van der Toorn
(A)
Willem Otte
(W)
Caroline van Heijningen
(C)
Sarah Durston
(S)
Vincent Mensen
(V)
Bob Oranje
(B)
René Mandl
(R)
Daphna Joel
(D)
John Cryan
(J)
Tracey Petryshen
(T)
David Pauls
(D)
Mai Saito
(M)
Angelique Heckman
(A)
Sabine Bahn
(S)
Ameli Schwalber
(A)
Ioana Florea
(I)
Informations de copyright
© 2022. The Author(s).
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