The Caspofungin Paradoxical Effect is a Tolerant "Eagle Effect" in the Filamentous Fungal Pathogen
Aspergillus fumigatus
Eagle effect
caspofungin
drug heterogeneity
tolerance
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
15
4
2022
medline:
1
7
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
Cell responses against antifungals other than resistance have rarely been studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasingly examined in yeast-like organisms. Aspergillus fumigatus is a filamentous fungal pathogen that causes a disease named aspergillosis, for which caspofungin (CAS), a fungistatic drug, is used as a second-line therapy. Some A. fumigatus clinical isolates can survive and grow in CAS concentrations above the minimum effective concentration (MEC), a phenomenon known as "caspofungin paradoxical effect" (CPE). Here, we evaluated the CPE in 67 A. fumigatus clinical isolates by calculating recovery rate (RR) values, where isolates with an RR of ≥0.1 were considered CPE
Identifiants
pubmed: 35420487
doi: 10.1128/mbio.00447-22
pmc: PMC9239232
doi:
Substances chimiques
Antifungal Agents
0
Echinocandins
0
Fungal Proteins
0
Caspofungin
F0XDI6ZL63
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0044722Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI153356
Pays : United States
Organisme : Wellcome Trust (WT)
ID : 219551/Z/19/Z
Organisme : Wellcome Trust (WT)
ID : 208396/Z/17/Z
Références
Science. 1948 Jan 9;107(2767):44-5
pubmed: 17778247
Ann N Y Acad Sci. 2015 Sep;1354:1-11
pubmed: 26190298
Curr Opin Infect Dis. 2015 Dec;28(6):514-22
pubmed: 26524326
Nat Rev Microbiol. 2020 Jun;18(6):319-331
pubmed: 32047294
Mol Microbiol. 2008 Mar;67(6):1274-91
pubmed: 18298443
Cell Host Microbe. 2019 Oct 9;26(4):453-462
pubmed: 31600499
Antimicrob Agents Chemother. 2015 Dec;59(12):7771-8
pubmed: 26459890
Genetics. 2022 Jan 4;220(1):
pubmed: 34718550
Nat Rev Drug Discov. 2017 Sep;16(9):603-616
pubmed: 28496146
mBio. 2017 Jun 13;8(3):
pubmed: 28611248
Drug Resist Updat. 2015 Nov;23:12-19
pubmed: 26690338
mBio. 2020 Aug 18;11(4):
pubmed: 32817108
Infect Dis Clin North Am. 2021 Jun;35(2):279-311
pubmed: 34016279
Drugs. 2017 Apr;77(6):599-613
pubmed: 28236169
Infect Dis Clin North Am. 2017 Sep;31(3):475-487
pubmed: 28687215
Antimicrob Agents Chemother. 2017 Nov 22;61(12):
pubmed: 28923871
Nat Rev Microbiol. 2016 Apr;14(5):320-30
pubmed: 27080241
Antimicrob Agents Chemother. 2019 Jul 25;63(8):
pubmed: 31138565
Annu Rev Microbiol. 2017 Sep 8;71:753-775
pubmed: 28886681
Antimicrob Agents Chemother. 2015 Aug;59(8):4946-55
pubmed: 26055379
Trends Microbiol. 2019 Apr;27(4):339-354
pubmed: 30448198
Antimicrob Agents Chemother. 2010 Apr;54(4):1555-63
pubmed: 20124000
J Fungi (Basel). 2017 Oct 18;3(4):
pubmed: 29371573