Effect of delayed versus immediate umbilical cord clamping in vaginal delivery at term: A randomized clinical trial.
cord clamping
hemoglobin
umbilical cord
vaginal delivery
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
17
03
2022
received:
18
07
2021
accepted:
11
04
2022
pubmed:
17
4
2022
medline:
16
11
2022
entrez:
16
4
2022
Statut:
ppublish
Résumé
To compare maternal blood loss with immediate cord clamping versus delayed cord clamping in women undergoing spontaneous vaginal delivery at term. Parallel group non-blinded randomized trial conducted at a single center in Italy. Women with singleton gestations who underwent spontaneous vaginal delivery at term were eligible and were randomized in a 1:1 ratio to either immediate or delayed cord clamping. In the immediate cord clamping group, cord clamping was within 15 s after birth. In the delayed cord clamping group, cord clamping was after more than 60 s, or when the cord had stopped pulsing. The primary outcome was change in maternal hemoglobin level from the day of delivery to day one after delivery. A total of 122 participants were enrolled in the trial. There were no significant differences in maternal blood loss as assessed by comparing the decrease in maternal hemoglobin level (mean difference - 0.10 g/dl, 95% confidence interval - 0.28 to 0.08) between the two groups. The mean hemoglobin level at postdelivery day 1 was 11.0 ± 1.5 g/dl in the delayed group and 11.3 ± 1.6 g/dl in the immediate group. Delayed umbilical cord clamping, compared with immediate umbilical cord clamping, resulted in no significant change in maternal hemoglobin level 1 day after delivery. Clinicaltrials.gov NCT04353544.
Identifiants
pubmed: 35428979
doi: 10.1002/ijgo.14223
pmc: PMC9790594
doi:
Substances chimiques
Hemoglobins
0
Banques de données
ClinicalTrials.gov
['NCT04353544']
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
898-902Informations de copyright
© 2022 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.
Références
J Matern Fetal Neonatal Med. 2020 Oct;33(19):3368-3376
pubmed: 30704334
Acta Obstet Gynecol Scand. 2016 Jul;95(7):837
pubmed: 26928792
Lancet. 2010 May 22;375(9728):1762-3
pubmed: 20494713
J Matern Fetal Neonatal Med. 2019 Dec;32(23):3998-4004
pubmed: 29890882
Cochrane Database Syst Rev. 2019 Feb 13;2:CD007412
pubmed: 30754073
JAMA. 2019 Nov 19;322(19):1869-1876
pubmed: 31742629
Sci Rep. 2020 Dec 9;10(1):21546
pubmed: 33298992
Cochrane Database Syst Rev. 2019 Apr 29;4:CD001808
pubmed: 31032882
Int J Gynaecol Obstet. 2022 Dec;159(3):898-902
pubmed: 35428979
Acta Obstet Gynecol Scand. 2013 May;92(5):567-74
pubmed: 22913332
Acta Obstet Gynecol Scand. 2016 Jan;95(1):28-37
pubmed: 26698831
Cochrane Database Syst Rev. 2013 Jul 11;(7):CD004074
pubmed: 23843134
Eur J Obstet Gynecol Reprod Biol. 2018 Apr;223:64-67
pubmed: 29499526
J Matern Fetal Neonatal Med. 2020 May;33(10):1744-1748
pubmed: 30257588
Arch Gynecol Obstet. 2019 Sep;300(3):531-543
pubmed: 31203386
Am Fam Physician. 2017 Apr 1;95(7):442-449
pubmed: 28409600
J Matern Fetal Neonatal Med. 2020 Mar;33(5):869-874
pubmed: 30122082
Lancet. 2006 Apr 1;367(9516):1066-1074
pubmed: 16581405
Cochrane Database Syst Rev. 2019 Sep 17;9:CD003248
pubmed: 31529790
BJOG. 2018 Jun;125(7):778-781
pubmed: 28881415