CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
CpG Island
DNA methylation
Epigenetic
Medullary thyroid cancer
RAP1GAP
Journal
Archives of Iranian medicine
ISSN: 1735-3947
Titre abrégé: Arch Iran Med
Pays: Iran
ID NLM: 100889644
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
26
10
2020
accepted:
07
02
2021
entrez:
17
4
2022
pubmed:
18
4
2022
medline:
20
4
2022
Statut:
epublish
Résumé
Medullary thyroid cancer (MTC) is a rare type of neuroendocrine tumor. This study aimed to investigate the gene and protein expression of In this case-control study, we selected 55 individuals who underwent thyroidectomy in Erfan hospital, Tehran, between 2018 and 2020. Samples were divided into normal thyroid tissues (control; n=20), benign nodule (n=20), and MTC (n=15). DNA methylation patterns were investigated using MSP (methylation-specific PCR). The protein level and mRNA expression of The hyper-methylation rates of CpG24 and CpG74 Hyper-methylation in CpG24 and CpG74
Sections du résumé
BACKGROUND
Medullary thyroid cancer (MTC) is a rare type of neuroendocrine tumor. This study aimed to investigate the gene and protein expression of
METHODS
In this case-control study, we selected 55 individuals who underwent thyroidectomy in Erfan hospital, Tehran, between 2018 and 2020. Samples were divided into normal thyroid tissues (control; n=20), benign nodule (n=20), and MTC (n=15). DNA methylation patterns were investigated using MSP (methylation-specific PCR). The protein level and mRNA expression of
RESULTS
The hyper-methylation rates of CpG24 and CpG74
CONCLUSION
Hyper-methylation in CpG24 and CpG74
Identifiants
pubmed: 35429959
doi: 10.34172/aim.2022.29
doi:
Substances chimiques
GTPase-Activating Proteins
0
RAP1GAP protein, human
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-177Informations de copyright
2022 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.