Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase.
Alternaria alternata
Alternariol
Callicarpa kwangtungensis Chun
Hyperuricemia
Xanthine oxidase
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
received:
10
02
2022
revised:
04
04
2022
accepted:
11
04
2022
pubmed:
18
4
2022
medline:
11
5
2022
entrez:
17
4
2022
Statut:
ppublish
Résumé
Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, which is further converted to uric acid. The excessive production or reduced excretion of the purine terminal metabolite may lead to hyperuricemia. In our ongoing search for new xanthine oxidase inhibitors, 14 endophytic fungi were isolated for the first time from a medicinal plant Callicarpa kwangtungensis Chun, and the ethyl acetate extracts of their culture filtrates were screened for XO inhibitory activity. The extract from an endophytic fungus, characterized as Alternaria alternata GDZZ-J6, exhibited the most potent inhibition of XO. Further fractionation of its secondary metabolites led to the isolation of six compounds. Among them, mycotoxin alternariol (AOH), a dibenzo-α-pyrone derivative, had strong inhibitory activity on XO, and the IC
Identifiants
pubmed: 35430257
pii: S0009-2797(22)00153-3
doi: 10.1016/j.cbi.2022.109948
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Lactones
0
Mycotoxins
0
Lead
2P299V784P
Xanthine Oxidase
EC 1.17.3.2
alternariol
KN9L4260JW
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109948Informations de copyright
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