Protective effect of d-alanine against acute kidney injury.

Acute Kidney Injury / metabolism Alanine / therapeutic use Animals Apoptosis / genetics Biomarkers Humans Hypoxia Ischemia Mice N-Methylaspartate Reactive Oxygen Species / metabolism Receptors, N-Methyl-D-Aspartate Reperfusion Injury / metabolism
acute kidney injury d-alanine mitochondria

Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 06 2022
Historique:
pubmed: 19 4 2022
medline: 18 5 2022
entrez: 18 4 2022
Statut: ppublish

Résumé

Recent studies have revealed the connection between amino acid chirality and diseases. We have previously reported that the gut microbiota produces various d-amino acids in a murine acute kidney injury (AKI) model. Here, we further explored the pathophysiological role of d-alanine (d-Ala) in AKI. Levels of d-Ala were evaluated in a murine AKI model. We analyzed transcripts of the

Identifiants

DOI: 10.1152/ajprenal.00198.2021 PMID: 35435002
pubmed: 35435002
doi: 10.1152/ajprenal.00198.2021
doi:

Substances chimiques

Biomarkers 0
Reactive Oxygen Species 0
Receptors, N-Methyl-D-Aspartate 0
N-Methylaspartate 6384-92-5
Alanine OF5P57N2ZX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

F667-F679

Auteurs

Yasunori Iwata (Y)

Division of Infection Control, Kanazawa University Hospital, Kanazawa, Japan.
Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.
ORCID: 0000-0002-4756-5207

Yusuke Nakade (Y)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Shinji Kitajima (S)

Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Shiori Yoneda-Nakagawa (S)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Megumi Oshima (M)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Norihiko Sakai (N)

Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Hisayuki Ogura (H)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.
ORCID: 0000-0001-9004-3837

Koichi Sato (K)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Tadashi Toyama (T)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Yuta Yamamura (Y)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Taro Miyagawa (T)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Hiroka Yamazaki (H)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Akinori Hara (A)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Miho Shimizu (M)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Kengo Furuichi (K)

Division of Nephrology, Kanazawa Medical University School of Medicine, Kanazawa, Japan.

Masashi Mita (M)

KAGAMI Incorporated, Osaka, Japan.

Kenji Hamase (K)

Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Tomohiro Tanaka (T)

National Institute for Physiological Sciences and Exploratory Research Center on Life and Living Systems and Center for Novel Science Initiatives, National Institutes of Natural Sciences, Aichi, Japan.

Motohiro Nishida (M)

Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
National Institute for Physiological Sciences and Exploratory Research Center on Life and Living Systems and Center for Novel Science Initiatives, National Institutes of Natural Sciences, Aichi, Japan.
ORCID: 0000-0002-2587-5458

Wataru Muramatsu (W)

Molecular Catalyst Research Center, Chubu University, Aichi, Japan.
ORCID: 0000-0001-7183-7981

Hisashi Yamamoto (H)

Molecular Catalyst Research Center, Chubu University, Aichi, Japan.

Shigeyuki Shichino (S)

Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Chiba; Tokyo University of Science, Tokyo, Japan.

Satoshi Ueha (S)

Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Chiba; Tokyo University of Science, Tokyo, Japan.

Kouji Matsushima (K)

Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Chiba; Tokyo University of Science, Tokyo, Japan.

Takashi Wada (T)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Protective effect of d-alanine against acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Alanine › Protective effect of d-alanine against acute...
questionsmedicales.fr › Eucaryotes › Animaux › Protective effect of d-alanine against acute...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Protective effect of d-alanine against acute...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Protective effect of d-alanine against acute...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protective effect of d-alanine against acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Protective effect of d-alanine against acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Protective effect of d-alanine against acute...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective effect of d-alanine against acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés dicarboxyliques › N-Méthyl-aspartate › Protective effect of d-alanine against acute...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Protective effect of d-alanine against acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Protective effect of d-alanine against acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Protective effect of d-alanine against acute...