Group B Streptococcal Colonization among Pregnant Women and Neonates in a Tertiary Care Hospital in South India.
Infant, Newborn
Female
Pregnancy
Humans
Clindamycin
/ therapeutic use
Pregnant Women
Prospective Studies
Tertiary Care Centers
Infectious Disease Transmission, Vertical
/ prevention & control
Streptococcus agalactiae
Streptococcal Infections
/ drug therapy
Anti-Bacterial Agents
/ therapeutic use
Sepsis
/ drug therapy
Colonization
Group B Streptococcus
Neonatal/Newborn
Pregnant women
Prevalence
Risk factors
Streptococcus agalactiae
Journal
Indian journal of pediatrics
ISSN: 0973-7693
Titre abrégé: Indian J Pediatr
Pays: India
ID NLM: 0417442
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
30
04
2021
accepted:
12
11
2021
pubmed:
20
4
2022
medline:
26
11
2022
entrez:
19
4
2022
Statut:
ppublish
Résumé
To assess the prevalence of maternal and neonatal group B Streptococcal colonization, incidence of neonatal systemic illness, and antibiotic sensitivity of isolates. This prospective cohort study was conducted in a South Indian tertiary care hospital. Rectovaginal swabs from pregnant mothers at 36 Of the 310 mothers, 40 were GBS colonized (prevalence: 12.9%; 95% CI 9.2%, 17.6%). None of the neonates were colonized. Maternal GBS colonization was significantly associated with premature rupture of membrane (RR - 2.93, 95% CI - 1.66-5.16) and neonatal systemic illness (RR - 2.78, 95% CI - 1.39-5.54). Positive correlation was noted between duration of IAP ≤ 4 h and neonatal illness and between maternal GBS colonization and Apgar at 1 min ≤ 4. Clindamycin resistance was noted in 20%. All neonates remained well at 3 mo follow-up. High maternal colonization alerts the need for GBS screening in India. Clindamycin resistance among GBS isolates questions its effectiveness as alternative therapy in penicillin allergy.
Identifiants
pubmed: 35438474
doi: 10.1007/s12098-022-04120-4
pii: 10.1007/s12098-022-04120-4
pmc: PMC9017074
doi:
Substances chimiques
Clindamycin
3U02EL437C
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1187-1194Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. Dr. K C Chaudhuri Foundation.
Références
Mukesi M, Iweriebor BC, Obi LC, Nwodo UU, Moyo SR, Okoh AI. Prevalence and capsular type distribution of Streptococcus agalactiae isolated from pregnant women in Namibia and South Africa. BMC Infect Dis. 2019;19:179.
doi: 10.1186/s12879-019-3809-6
pubmed: 30786878
pmcid: 6383256
Vinod R, Govindan S, Manju M. Prevalence and antibiotic pattern of group B streptococcus among antenatal women attending a tertiary care centre in Puducherry. Indian J Microbiol Res. 2018;5:466–9.
Verani JR, McGee L, Schrag SJ. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59:1–36.
Prevention of group B streptococcal early-onset disease in newborns: ACOG Committee Opinion, Number 782. Obstet Gynecol. 2019;134:e19–4
Puopolo KM, Baker CJ. Group B Streptococcal infection in neonates and young infants. UpToDate. 2021. Available at: https://www.uptodate.com/contents/group-b-streptococcal-infection-in-neonates-and-young-infants . Accessed on 20 April 2021.
Filkins L, Hauser JR, Robinson-Dunn B, Tibbetts R, Boyanton BL, Revell P. American Society for Microbiology provides 2020 guidelines for detection and identification of group B streptococcus. J Clin Microbiol. 2020;59:e01230-e1320.
Patil KP, Singla SS, Nagmoti MB, Swamy MK. Group B streptococci colonization in pregnant women: is screening necessary? JSAFOG. 2013;5:64–67
Dalal BS, Lahiri A, Parel CC. Carriage rate of group B streptococci in pregnant women and evaluation of different isolation media. J Indian Med Assoc. 1998;96:360–1.
pubmed: 10489749
Santhanam S, Jose R, Sahni RD, Thomas N, Beck MM. Prevalence of group B Streptococcal colonization among pregnant women and neonates in a tertiary hospital in India. J Turk GerGynecol Assoc. 2017;18:181–4.
Das A, Ray P, Sharma M, Gopalan S. Rapid diagnosis of vaginal carriage of group B beta haemolytic streptococcus by an enrichment cum antigen detection test. Indian J Med Res. 2003;117:247–52.
pubmed: 14748470
Sharmila V, Joseph NM, Arun Babu T, Chaturvedula L, Sistla S. Genital tract group B streptococcal colonization in pregnant women:a south indian perspective. J Infect Dev Ctries. 2011;5:592–5.
doi: 10.3855/jidc.1551
pubmed: 21841303
Dechen TC, Sumit K, RanabirP. Correlates of vaginal colonization with group B streptococci among pregnant women. J Glob Infect Dis. 2010;2:236–41.
Chaudhary M, Rench MA, Baker CJ, Singh P, Hans C, Edwards MS. Group B streptococcal colonization among pregnant women in Delhi. India Pediatr Infect Dis J. 2017;36:665–9.
doi: 10.1097/INF.0000000000001514
pubmed: 28027278
Konikkara KP, Baliga S, Shenoy S, Bharati B. Evaluation of culture, antigen detection and polymerase chain reaction for detection of vaginal colonization of group B streptococcus (GBS) in pregnant women. J Clin Diagn Res. 2014;8:47–54.
Khatoon F, Nigam A, Sharma NR, Srivastava R, Sangal R, Malik N. Prevalence and risk factors for group B streptococcal colonization in pregnant women in northern India. Int J Reprod Contracept Obstet. 2016;5:4361–4.
doi: 10.18203/2320-1770.ijrcog20164343
Kulkarni AA, Pawar SG, Dharmadhikari CA, Kulkarni RD. Colonization of pregnant women and their newborn infants with group–B streptococci. Indian J Med Microbiol. 2001;19:1–4.
doi: 10.1016/S0255-0857(21)03363-6
pubmed: 17664797
Russell NJ, Seale AC, O'Driscoll M, et al. GBS Maternal Colonization Investigator Group. Maternal colonization with group B streptococcus and serotype distribution worldwide: systematic review and meta-analyses. Clin Infect Dis. 2017;65:S100–11.
Gizachew M, Tiruneh M, MogesF, Adefris M, Tigabu Z, Tessema B. Streptococcus agalactiae from Ethiopian pregnant women; prevalence, associated factors and antimicrobial resistance: alarming for prophylaxis. Ann Clin Microbiol Antimicrob. 2019;18:3.
El Aila NA, Esleem SE, Elmanama AA. Prevalence of group B streptococcus colonization among pregnant women in Gaza strip. Palestine IUG J Nat Stud. 2017;25:1–12.
Lekala LM, Mavenyengwa RT, Moyo SR, et al. Risk factors associated with group B streptococcus colonization and their effect on pregnancy outcome. J Gynecol Obstet. 2015;3:121–8.
doi: 10.11648/j.jgo.20150306.14
Tsolia M, Psoma M, Gavrili S, et al. Group B streptococcus colonization of Greek pregnant women and neonates: prevalence, risk factors and serotypes. Clin Microbiol Infect. 2003;9:832–8.
Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm Rep. 2002;51:1–22
Mengist A, Kannan H, Abdissa A. Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma. Ethiopia BMC Res Notes. 2016;9:351.
Angelis D, Mudduluru M, Joseph S, Ching C, Hughes A, Bennett R. Neonatal adrenal findings: significance and diagnostic approach. description of two cases. Clin Case Rep. 2018;6:658–63.
Shah D, Saxena S, Randhawa VS, Nangia S, Dutta R. Prospective analysis of risk factors associated with group B streptococcal colonisation in neonates born at a tertiary care centre in India. Paediatr Int Child Health. 2014;34:184–8.
doi: 10.1179/2046905513Y.0000000112
pubmed: 24621242
Bolukaoto JY, Monyama CM, Chukwu MO, et al. Antibiotic resistance of Streptococcus agalactiae isolated from pregnant women in Garankuwa. South Africa BMC Res Notes. 2015;8:364.
doi: 10.1186/s13104-015-1328-0
pubmed: 26289147
Jisuvei SC, Osoti A, Njeri MA. Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcusrectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; a cross-sectional study. BMC Infect Dis. 2020;20:302.
doi: 10.1186/s12879-020-05035-1
pubmed: 32321444
pmcid: 7178604
Ji W, Zhang L, Guo Z, et al. Colonization prevalence and antibiotic susceptibility of group B streptococcus in pregnant women over a 6–year period in Dongguan, China. PLoS One. 2017;12:e0183083.
Kohli-Lynch M, Russell NJ, Seale AC, et al. Neurodevelopmental impairment in children after group B streptococcal disease worldwide: systematic review and meta-analyses. Clin Infect Dis. 2017;65:S190–9.
doi: 10.1093/cid/cix663
pubmed: 29117331
pmcid: 5848372
Tann CJ, Martinello KA, Sadoo S, et al. GBS Neonatal Encephalopathy Investigator Group. Neonatal encephalopathy with group B streptococcal disease worldwide: systematic review, investigator group datasets, and meta-analysis. Clin Infect Dis. 2017;65:S173–89.