Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.

Benchmarking Luciferases Proteolysis Tacrolimus Binding Protein 1A / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
19 04 2022
Historique:
received: 22 04 2021
accepted: 25 03 2022
entrez: 20 4 2022
pubmed: 21 4 2022
medline: 22 4 2022
Statut: epublish

Résumé

Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12

Identifiants

DOI: 10.1038/s41467-022-29670-1 PMID: 35440107 PMC: PMC9019100
pubmed: 35440107
doi: 10.1038/s41467-022-29670-1
pii: 10.1038/s41467-022-29670-1
pmc: PMC9019100
doi:

Substances chimiques

Luciferases EC 1.13.12.-
nanoluc EC 1.13.12.-
Tacrolimus Binding Protein 1A EC 5.2.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2073

Informations de copyright

© 2022. Crown.

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Auteurs

Christoph Grohmann (C)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Charlene M Magtoto (CM)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Joel R Walker (JR)

Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA.

Ngee Kiat Chua (NK)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Anna Gabrielyan (A)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Mary Hall (M)

Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA.

Simon A Cobbold (SA)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.

Stephen Mieruszynski (S)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Martin Brzozowski (M)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Daniel S Simpson (DS)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Hao Dong (H)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Bridget Dorizzi (B)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0002-7557-5445

Annette V Jacobsen (AV)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0003-0252-7685

Emma Morrish (E)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

Natasha Silke (N)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.

James M Murphy (JM)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0003-0195-3949

Joan K Heath (JK)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0001-6955-232X

Andrea Testa (A)

Amphista Therapeutics Ltd, Bo'Ness Road Newhouse, Glasgow, ML1 5UH, UK.
ORCID: 0000-0002-8973-9711

Chiara Maniaci (C)

Chemistry School of Natural and Environmental Sciences, Bedson Building, Newcastle University Edwards Walk, Newcastle, NE1 8QB, UK.
ORCID: 0000-0001-7887-7388

Alessio Ciulli (A)

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
ORCID: 0000-0002-8654-1670

Guillaume Lessene (G)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0002-1193-8147

John Silke (J)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
ORCID: 0000-0002-7611-5774

Rebecca Feltham (R)

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia. feltham.r@wehi.edu.au.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. feltham.r@wehi.edu.au.
ORCID: 0000-0001-8376-6869

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Classifications MeSH

questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation de programme › Référenciation › Development of NanoLuc-targeting protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Luciferases › Development of NanoLuc-targeting protein...
questionsmedicales.fr › Métabolisme › Protéolyse › Development of NanoLuc-targeting protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs des médicaments › Immunophilines › Protéines de liaison au tacrolimus › Protéine 1A de liaison au tacrolimus › Development of NanoLuc-targeting protein...