The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial.
Adults
Australia
Diabetes prevention
General practice
Get healthy
Prediabetes
Prevention
Randomized controlled trial
Zinc supplementation
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
03
03
2022
accepted:
30
03
2022
pubmed:
23
4
2022
medline:
3
6
2022
entrez:
22
4
2022
Statut:
ppublish
Résumé
The burden and health costs of Type 2 Diabetes Mellitus continue to increase globally and prevention strategies in at-risk people need to be explored. Previous work, in both animal models and humans, supports the role of zinc in improving glucose homeostasis. We, therefore, aimed to test the effectiveness of zinc supplementation on glycaemic control in pre-diabetic adults. We conducted a randomized, double-blind, placebo-controlled trial across 10 General Practitioner (GP) practices in NSW, Australia. The trial is known as Zinc in Preventing the Progression of pre-Diabetes (ZIPPeD)Study. Pre-diabetic (haemoglobin A1c [HbA1c] 5.7-6.4%, 39-46 mmol/mol) men and women (N = 98) were all assigned to a free state government telephone health coaching service (New South Wales Get Healthy Information and Coaching Service) and then randomised to either daily 30 mg zinc gluconate or placebo. Blood tests were collected at baseline, 1, 6 and 12 months for the primary outcomes (HbA1c, fasting blood glucose (FBG)); secondary outcomes included Homeostasis Model Assessment 2 (HOMA 2) parameters, lipids, body weight, height, waist circumference, blood pressure and pulse. The baseline-adjusted mean group difference at 6 months, expressed as treatment-placebo, (95% CI) was -0.02 (-0.14, 0.11, p = 0.78) for HbA1c and 0.17 (-0.07, 0.42; p = 0.17) for FBG, neither of which were statistically significant. There were also no significant differences between groups in any of the secondary outcomes. Zinc was well tolerated, and compliance was high (88%). We believe our results are consistent with other Western clinical trial studies and do not support the use of supplemental zinc in populations with a Western diet. There may still be a role for supplemental zinc in the developing world where diets may be zinc deficient. Australian and New Zealand Clinical Trials Registry, ACTRN12618001120268. Registered on 6 July 2018.
Identifiants
pubmed: 35451678
doi: 10.1007/s00592-022-01888-x
pii: 10.1007/s00592-022-01888-x
pmc: PMC9026040
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
965-975Subventions
Organisme : NSW Ministry of Health
ID : G18/31636
Informations de copyright
© 2022. The Author(s).
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