Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma.
W256 carcinoma
anti-tumour activity
iron oxide nanoparticles
magnetic hyperthermia
oleic acid
toxicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Apr 2022
11 Apr 2022
Historique:
received:
24
03
2022
revised:
04
04
2022
accepted:
05
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.
Identifiants
pubmed: 35457052
pii: ijms23084234
doi: 10.3390/ijms23084234
pmc: PMC9025391
pii:
doi:
Substances chimiques
Magnetite Nanoparticles
0
Oleic Acid
2UMI9U37CP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 19-29-10013
Références
Br J Cancer. 1991 Oct;64(4):631-44
pubmed: 1911211
Oncol Lett. 2014 Mar;7(3):764-770
pubmed: 24527084
Cell Prolif. 1995 Nov;28(11):617-30
pubmed: 8555374
J Neurooncol. 2019 Jan;141(1):83-94
pubmed: 30506500
Nanomedicine (Lond). 2018 Apr;13(8):953-971
pubmed: 29376469
Nutr Rev. 1999 Apr;57(4):114-23
pubmed: 10228348
Nat Rev Cancer. 2014 Mar;14(3):199-208
pubmed: 24561446
ACS Nano. 2013 Aug 27;7(8):7132-44
pubmed: 23899269
Mol Cell. 2010 Oct 22;40(2):253-66
pubmed: 20965420
Nanomaterials (Basel). 2019 Oct 18;9(10):
pubmed: 31635415
Sci Rep. 2018 Feb 1;8(1):2082
pubmed: 29391477
Int J Mol Sci. 2013 Oct 25;14(11):21266-305
pubmed: 24232575
Nat Rev Cancer. 2004 Nov;4(11):839-49
pubmed: 15516957
Nanomaterials (Basel). 2016 Jun 06;6(6):
pubmed: 28335233
Biochem J. 2014 Aug 15;462(1):25-37
pubmed: 24854545
Int J Hyperthermia. 2017 Feb;33(1):3-14
pubmed: 27492859
Int J Hyperthermia. 2001 Nov-Dec;17(6):499-507
pubmed: 11719966
Pathol Oncol Res. 2020 Jul;26(3):1879-1892
pubmed: 31820302
J Zhejiang Univ Sci B. 2008 Sep;9(9):707-12
pubmed: 18763303
Clin Radiol. 2019 Jan;74(1):80.e19-80.e26
pubmed: 30447997
Int J Hyperthermia. 2020;37(1):506-516
pubmed: 32423261
Int J Cancer. 2011 Oct 15;129(8):1970-8
pubmed: 21154744
Radiology. 2017 Jul;284(1):272-280
pubmed: 28076721
Bull Exp Biol Med. 2009 Sep;148(3):447-51
pubmed: 20396709
Curr Top Med Chem. 2014 Mar;14(5):572-94
pubmed: 24444167
Int J Hyperthermia. 2013 Dec;29(8):777-89
pubmed: 24099465
Toxicology. 2018 Aug 1;406-407:81-91
pubmed: 29885472
Nanomaterials (Basel). 2018 Oct 09;8(10):
pubmed: 30304823
Nanomaterials (Basel). 2015 Jan 09;5(1):63-89
pubmed: 28347000
Cancer Res. 1993 Jun 15;53(12):2740-4
pubmed: 8504414
Colloids Surf B Biointerfaces. 2021 Mar;199:111548
pubmed: 33421925
Int J Hyperthermia. 2018 Dec;34(8):1316-1328
pubmed: 29353516
Oncotarget. 2017 Jun 21;8(40):67254-67268
pubmed: 28978031
J Zhejiang Univ Sci B. 2008 Mar;9(3):261-4
pubmed: 18357629
Nanoscale. 2016 Oct 14;8(38):16902-15
pubmed: 27427416
Cell Physiol Biochem. 2017;44(5):1949-1964
pubmed: 29224009
Environ Toxicol Pharmacol. 2016 Jul;45:321-7
pubmed: 27375215
Cancer Treat Rev. 2013 Dec;39(8):862-71
pubmed: 23601905
Biomaterials. 2012 Sep;33(27):6408-19
pubmed: 22681980
Oncotarget. 2016 Dec 20;7(51):84082-84092
pubmed: 27556507
Nanomaterials (Basel). 2020 Sep 25;10(10):
pubmed: 32993001
Langmuir. 2017 Feb 21;33(7):1662-1669
pubmed: 28146360
Nanotoxicology. 2019 May;13(4):510-526
pubmed: 30704361
Biomater Sci. 2018 Jul 24;6(8):2219-2229
pubmed: 29985495
Radiology. 2012 Jun;263(3):900-8
pubmed: 22495684