Binding Interaction of Betulinic Acid to α-Glucosidase and Its Alleviation on Postprandial Hyperglycemia.

Animals Diabetes Mellitus, Type 2 / drug therapy Glycoside Hydrolase Inhibitors / chemistry Hyperglycemia / drug therapy Mice Molecular Docking Simulation Pentacyclic Triterpenes / chemistry alpha-Glucosidases / chemistry Betulinic Acid
betulinic acid inhibition mechanism postprandial hyperglycemia synergistic effect α-glucosidase

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
13 Apr 2022
Historique:
received: 20 02 2022
revised: 02 04 2022
accepted: 07 04 2022
entrez: 23 4 2022
pubmed: 24 4 2022
medline: 27 4 2022
Statut: epublish

Résumé

Inhibiting the intestinal α-glucosidase can effectively control postprandial hyperglycemia for type 2 diabetes mellitus (T2DM) treatment. In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on α-glucosidase and its alleviation on postprandial hyperglycemia. BA was verified to exhibit a strong inhibitory effect against α-glucosidase with an IC

Identifiants

DOI: 10.3390/molecules27082517 PMID: 35458714 PMC: PMC9032457
pubmed: 35458714
pii: molecules27082517
doi: 10.3390/molecules27082517
pmc: PMC9032457
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
Pentacyclic Triterpenes 0
alpha-Glucosidases EC 3.2.1.20
Betulinic Acid 4G6A18707N

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 81803393
Organisme : National Natural Science Foundation of China
ID : 31901696
Organisme : Guangdong Basic and Applied Basic Research Foundation
ID : 2020A1515011337
Organisme : Guangdong Province Science and Technology Project
ID : 2019A050520003
Organisme : Science and Technology Planning Project of Guangzhou
ID : 202102021263
Organisme : Guangdong Province Agriculture Research Project & Agricultural Technique Promotion Project
ID : 2021KJ103
Organisme : GDAS' Project of Science and Technology Development
ID : 2020GDASYL-20200104016

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Auteurs

Shaodan Chen (S)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.

Bing Lin (B)

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Jiangyong Gu (J)

Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Tianqiao Yong (T)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.

Xiong Gao (X)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.

Yizhen Xie (Y)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.

Chun Xiao (C)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.

Janis Yaxian Zhan (JY)

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Qingping Wu (Q)

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Science, Guangzhou 510070, China.
ORCID: 0000-0001-6503-359X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Triterpènes pentacycliques › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Binding Interaction of Betulinic Acid to...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Triterpènes pentacycliques › Lupanes › Acide bétulinique › Binding Interaction of Betulinic Acid to...