Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1.
RNA
debranching enzyme
introns
lariats
metalloenzymes
metallophosphoesterase
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
09
03
2022
accepted:
11
04
2022
pubmed:
24
4
2022
medline:
22
6
2022
entrez:
23
4
2022
Statut:
ppublish
Résumé
In eukaryotic cells, intron lariats produced by the spliceosome contain a 2'5' phosphodiester linkage. The RNA lariat debranching enzyme, Dbr1, is the only enzyme known to hydrolyze this bond. Dbr1 is a member of the metallophosphoesterase (MPE) family of enzymes, and recent X-ray crystal structures and biochemistry data demonstrate that Dbr1 from
Identifiants
pubmed: 35459748
pii: rna.079159.122
doi: 10.1261/rna.079159.122
pmc: PMC9202583
doi:
Substances chimiques
Metals
0
RNA
63231-63-0
Dbr1 protein, human
EC 2.7.7.-
RNA Nucleotidyltransferases
EC 2.7.7.-
lariat debranching enzyme
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
927-936Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105681
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127472
Pays : United States
Informations de copyright
© 2022 Clark et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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