Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?
Journal
Sports medicine (Auckland, N.Z.)
ISSN: 1179-2035
Titre abrégé: Sports Med
Pays: New Zealand
ID NLM: 8412297
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
accepted:
17
03
2022
pubmed:
24
4
2022
medline:
25
10
2022
entrez:
23
4
2022
Statut:
ppublish
Résumé
In 1924, Otto Warburg asked "How does the metabolism of a growing tissue differ from that of a non-growing tissue?" Currently, we know that proliferating healthy and cancer cells reprogramme their metabolism. This typically includes increased glucose uptake, glycolytic flux and lactate synthesis. A key function of this reprogramming is to channel glycolytic intermediates and other metabolites into anabolic reactions such as nucleotide-RNA/DNA synthesis, amino acid-protein synthesis and the synthesis of, for example, acetyl and methyl groups for epigenetic modification. In this review, we discuss evidence that a hypertrophying muscle similarly takes up more glucose and reprogrammes its metabolism to channel energy metabolites into anabolic pathways. We specifically discuss the functions of the cancer-associated enzymes phosphoglycerate dehydrogenase and pyruvate kinase muscle 2 in skeletal muscle. In addition, we ask whether increased glucose uptake by a hypertrophying muscle explains why muscularity is often negatively associated with type 2 diabetes mellitus and obesity.
Identifiants
pubmed: 35460513
doi: 10.1007/s40279-022-01676-1
pii: 10.1007/s40279-022-01676-1
pmc: PMC9584876
doi:
Substances chimiques
Pyruvate Kinase
EC 2.7.1.40
Phosphoglycerate Dehydrogenase
EC 1.1.1.95
Glucose
IY9XDZ35W2
DNA
9007-49-2
Nucleotides
0
Amino Acids
0
Lactates
0
RNA
63231-63-0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2569-2578Subventions
Organisme : European Research Council
ID : 754462
Pays : International
Informations de copyright
© 2022. The Author(s).
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