Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
20
01
2022
revised:
01
04
2022
accepted:
15
04
2022
pubmed:
24
4
2022
medline:
29
6
2022
entrez:
23
4
2022
Statut:
ppublish
Résumé
To measure plasma levels of vascular endothelial growth factor (VEGF) and several cytokines (Interleukin [IL]-6 IL-8, IL-10) during the first week of life to examine the relationship between protein expression and likelihood of developing respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). Levels of IL-6, IL-8, IL-10, and VEGF were measured from plasma obtained from preterm patients during the first week of life. Newborns were recruited from a single center between April 2009 and April 2019. Criteria for the study included being inborn, birth weight of less than 1500 grams, and a gestational age of less than 32 weeks at birth. The development of RDS in preterm newborns was associated with lower levels of VEGF during the first week of life. Higher plasma levels of IL-6 and IL-8 plasma were associated with an increased likelihood and increased severity of BPD at 36 weeks postmenstrual age. In contrast, plasma levels of VEGF, IL-6, IL-8, and IL-10 obtained during the first week of life were not associated with respiratory symptoms and acute care use in young children with BPD in the outpatient setting. During the first week of life, lower plasma levels of VEGF was associated with the diagnosis of RDS in preterm infants. Preterm infants with higher levels of IL-6 and IL-8 during the first week of life were also more likely to be diagnosed with BPD. These biomarkers may help to predict respiratory morbidities in preterm newborns during their initial hospitalization.
Identifiants
pubmed: 35460699
pii: S0022-3476(22)00343-2
doi: 10.1016/j.jpeds.2022.04.028
pmc: PMC9264338
mid: NIHMS1820080
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Interleukin-6
0
Interleukin-8
0
Vascular Endothelial Growth Factor A
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-39.e3Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103538
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114800
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086058
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS096115
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Ann Am Thorac Soc. 2018 May;15(5):530-538
pubmed: 29328889
Pediatrics. 2008 Sep;122(3):479-85
pubmed: 18762515
J Pediatr. 2020 Nov;226:71-79.e5
pubmed: 32610169
Pediatrics. 2015 Apr;135(4):607-16
pubmed: 25733757
Kidney Int. 2006 May;69(10):1741-8
pubmed: 16572116
Pediatrics. 2015 Mar;135(3):e678-86
pubmed: 25647675
Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1160-9
pubmed: 19734318
J Interferon Cytokine Res. 2019 Nov;39(11):684-693
pubmed: 31268385
Pediatrics. 2010 Oct;126(4):632-7
pubmed: 20876173
Semin Perinatol. 1996 Jun;20(3):206-9
pubmed: 8870123
J Pediatr. 2016 Jul;174:45-51.e5
pubmed: 27117196
Cold Spring Harb Perspect Biol. 2014 Sep 04;6(10):a016295
pubmed: 25190079
Exp Lung Res. 2012 May;38(4):192-203
pubmed: 22394267
Adv Exp Med Biol. 2010;661:323-35
pubmed: 20204740
Neonatology. 2013;103(4):300-7
pubmed: 23548588
Pediatr Pulmonol. 2019 Mar;54(3):313-318
pubmed: 30609293
Pediatr Pulmonol. 2020 Feb;55(2):369-375
pubmed: 31804768
Cochrane Database Syst Rev. 2018 Jan 08;1:CD009734
pubmed: 29308602
Pediatr Pulmonol. 2011 Jul;46(7):709-16
pubmed: 21328574
Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1068-78
pubmed: 16829629
J Pediatr. 2009 Jan;154(1):39-43.e3
pubmed: 18760808
Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9
pubmed: 11401896
J Pediatr. 2018 Jun;197:300-308
pubmed: 29551318
BMC Res Notes. 2013 Dec 20;6:547
pubmed: 24359685
J Pediatr. 2020 Jul;222:85-90.e2
pubmed: 32417083
J Perinatol. 2020 Nov;40(11):1634-1643
pubmed: 32811975
Pediatrics. 2006 Jun;117(6):1901-6
pubmed: 16740829
Pediatr Pulmonol. 2005 May;39(5):461-5
pubmed: 15786439
J Matern Fetal Neonatal Med. 2016;29(11):1758-64
pubmed: 26135768
Pediatr Pulmonol. 2018 Aug;53(8):1046-1052
pubmed: 29687638
N Engl J Med. 2016 Sep 1;375(9):871-8
pubmed: 27579637
F1000Res. 2020 Jul 14;9:
pubmed: 32704351
Pediatrics. 2009 Apr;123(4):1132-41
pubmed: 19336372
Acta Paediatr. 2021 Jul;110(7):2084-2092
pubmed: 33624315
Tumour Biol. 2016 Sep;37(9):11553-11572
pubmed: 27260630
Cancer Treat Rev. 2017 Nov;60:24-31
pubmed: 28866366
Clin Perinatol. 2015 Dec;42(4):739-54
pubmed: 26593076