Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
Beta
Ki
Lambda
M(pro)
Omicron
PF-07321332
SARS-CoV-2
VOC
crystal structure
nirmatrelvir
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
28
02
2022
revised:
18
04
2022
accepted:
19
04
2022
pubmed:
25
4
2022
medline:
30
6
2022
entrez:
24
4
2022
Statut:
ppublish
Résumé
The COVID-19 pandemic continues to be a public health threat with emerging variants of SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the main protease (M
Identifiants
pubmed: 35461811
pii: S0021-9258(22)00412-4
doi: 10.1016/j.jbc.2022.101972
pmc: PMC9023115
pii:
doi:
Substances chimiques
Lactams
0
Nitriles
0
Viral Protease Inhibitors
0
Viral Proteins
0
nirmatrelvir
7R9A5P7H32
Proline
9DLQ4CIU6V
Cysteine Endopeptidases
EC 3.4.22.-
Coronavirus 3C Proteases
EC 3.4.22.28
Leucine
GMW67QNF9C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101972Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest All authors are employees of Pfizer, Inc and may hold or own shares of stock.
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