Perivascular adipose tissue modulates the effects of flavonoids on rat aorta rings: Role of superoxide anion and β
(-)-Epigallocatechin (PubChem CID: 72277)
(-)-Epigallocatechin gallate (PubChem CID: 65064)
(±)-Naringenin (PubChem CID: 932)
(±)-Taxifolin (PubChem CID: 439533)
Apigenin (PubChem CID: 5280443)
Chrysin (PubChem CID: 5281607)
Fisetin (PubChem CID: 5281614)
Flavonoids
Galangin (PubChem CID: 5281616)
Genistein (PubChem CID: 5280961)
Hesperetin (PubChem CID: 72281)
Hesperidin (PubChem CID: 68112)
Isorhamnetin (PubChem CID: 5281654)
Kaempferol (PubChem CID: 5280863)
Luteolin (PubChem CID: 5280445)
Morin (PubChem CID: 5281670)
PVAT
Quercetin (PubChem CID: 5280343)
Rat aorta rings
Resokaempferol (PubChem CID: 5281611)
Rutin (PubChem CID: 5280805)
Scutellarein (PubChem CID: 5281697)
Superoxide anion
Tamarixetin (PubChem CID: 5281699)
ꞵ(3) receptors
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
30
12
2021
revised:
14
03
2022
accepted:
19
04
2022
pubmed:
25
4
2022
medline:
28
5
2022
entrez:
24
4
2022
Statut:
ppublish
Résumé
Several studies demonstrate the beneficial effects of dietary flavonoids on the cardiovascular system. Since perivascular adipose tissue (PVAT) plays an active role in the regulation of vascular tone in both health and diseases, the present study aimed to assess the functional interaction between PVAT and flavonoids in vitro on rat aorta rings. Several flavonoids proved to display both antispasmodic and spasmolytic activities towards noradrenaline-induced contraction of rings deprived of PVAT (-PVAT). However, on PVAT-intact (+PVAT) rings, both actions of some flavonoids were lost and/or much decreased. In rings-PVAT, the superoxide donor pyrogallol mimicked the effect of PVAT, while in rings+PVAT the antioxidant mito-tempol restored both activities of the two most representative flavonoids, namely apigenin and chrysin. The Rho-kinase inhibitor fasudil, or apigenin and chrysin concentration-dependently relaxed the vessel active tone induced by the Rho-kinase activator NaF; the presence of PVAT counteracted apigenin spasmolytic activity, though only in the absence of mito-tempol. Similar results were obtained in rings pre-contracted by phenylephrine. Finally, when β
Identifiants
pubmed: 35462011
pii: S1043-6618(22)00176-1
doi: 10.1016/j.phrs.2022.106231
pii:
doi:
Substances chimiques
Flavonoids
0
Parasympatholytics
0
Superoxides
11062-77-4
Apigenin
7V515PI7F6
rho-Associated Kinases
EC 2.7.11.1
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106231Informations de copyright
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