Alcohol- and non-alcohol-related interference: An fMRI study of treatment-seeking adults with alcohol use disorder.

Adult Alcoholism / psychology Gyrus Cinguli / diagnostic imaging Humans Magnetic Resonance Imaging Reaction Time Stroop Test
Alcohol use disorder Anterior Cingulate Interference Stroop task fMRI

Journal

Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587

Informations de publication

Date de publication:
01 06 2022
Historique:
received: 23 11 2021
revised: 11 04 2022
accepted: 11 04 2022
pubmed: 25 4 2022
medline: 18 5 2022
entrez: 24 4 2022
Statut: ppublish

Résumé

Individuals with alcohol use disorder (AUD) have difficulty diverting attention away from alcohol-related stimuli and towards non-alcohol-related goals (i.e., alcohol-related attention interference). It remains unclear whether regulatory brain function differs during alcohol and non-alcohol-related interference. This study compares brain reactivity during the alcohol and classic Stroop and whether such brain function relates to AUD severity. 46 participants with AUD completed alcohol and classic color-word Stroop tasks during fMRI. Brain activity was compared during alcohol and classic Stroop interference in the rostral and dorsal anterior cingulate cortices (rACC and dACC) and correlated with self-reported AUD severity. Exploratory whole-brain analyses were also conducted. Behavioral interference (i.e., slower reaction times) was observed during alcohol and classic Stroop. rACC activity was significantly higher during the alcohol > neutral contrast versus the incongruent > congruent contrast. dACC activity did not differ between the Stroop tasks. dACC activity during incongruent > congruent was positively associated with AUD severity. Activity in ACC subregions differed during alcohol and non-alcohol interference. Increased alcohol-related activity in the rACC, a region linked to emotional conflict resolution, suggests an interfering effect of self-relevant alcohol cues on non-alcohol-related processing. AUD severity was related to greater dACC reactivity during classic Stroop interference, suggesting that non-drug-related cognitive control impairments are more pronounced in those with more problematic alcohol use.

Sections du résumé

BACKGROUND
Individuals with alcohol use disorder (AUD) have difficulty diverting attention away from alcohol-related stimuli and towards non-alcohol-related goals (i.e., alcohol-related attention interference). It remains unclear whether regulatory brain function differs during alcohol and non-alcohol-related interference. This study compares brain reactivity during the alcohol and classic Stroop and whether such brain function relates to AUD severity.
METHODS
46 participants with AUD completed alcohol and classic color-word Stroop tasks during fMRI. Brain activity was compared during alcohol and classic Stroop interference in the rostral and dorsal anterior cingulate cortices (rACC and dACC) and correlated with self-reported AUD severity. Exploratory whole-brain analyses were also conducted.
RESULTS
Behavioral interference (i.e., slower reaction times) was observed during alcohol and classic Stroop. rACC activity was significantly higher during the alcohol > neutral contrast versus the incongruent > congruent contrast. dACC activity did not differ between the Stroop tasks. dACC activity during incongruent > congruent was positively associated with AUD severity.
CONCLUSIONS
Activity in ACC subregions differed during alcohol and non-alcohol interference. Increased alcohol-related activity in the rACC, a region linked to emotional conflict resolution, suggests an interfering effect of self-relevant alcohol cues on non-alcohol-related processing. AUD severity was related to greater dACC reactivity during classic Stroop interference, suggesting that non-drug-related cognitive control impairments are more pronounced in those with more problematic alcohol use.

Identifiants

DOI: 10.1016/j.drugalcdep.2022.109462 PMID: 35462263 PMC: PMC9106927
pubmed: 35462263
pii: S0376-8716(22)00199-5
doi: 10.1016/j.drugalcdep.2022.109462
pmc: PMC9106927
mid: NIHMS1800324
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

109462

Subventions

Organisme : NIMH NIH HHS
ID : R56 MH117131
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA015923
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117131
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA015036
Pays : United States
Organisme : NIDA NIH HHS
ID : K02 DA042987
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Références

Nat Neurosci. 2016 Sep 27;19(10):1286-91
pubmed: 27669989
Biol Psychiatry. 2008 Dec 1;64(11):998-1004
pubmed: 18635157
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Neuroimage. 2004 Oct;23(2):483-99
pubmed: 15488398
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Neuroscientist. 2014 Apr;20(2):150-9
pubmed: 23835449
Psychopharmacology (Berl). 2017 Mar;234(6):1001-1015
pubmed: 28161772
Psychopharmacology (Berl). 2012 Apr;220(4):707-18
pubmed: 21989805
Addict Biol. 2010 Oct;15(4):491-503
pubmed: 20840335
Psychiatry Res Neuroimaging. 2019 Dec 30;294:111005
pubmed: 31715379
Neuron. 2006 Sep 21;51(6):871-82
pubmed: 16982430
Drug Alcohol Depend. 2016 Oct 01;167:75-81
pubmed: 27522872
Hum Brain Mapp. 2014 Sep;35(9):4282-92
pubmed: 24510765
Alcohol Clin Exp Res. 2017 Dec;41(12):2207-2216
pubmed: 28992377
Psychophysiology. 2007 May;44(3):343-51
pubmed: 17433093
Int J Methods Psychiatr Res. 2020 Mar;29(1):e1811
pubmed: 31808602
Neuroimage. 2019 Oct 15;200:313-331
pubmed: 31229660
Neuroimage. 2017 Jul 1;154:188-205
pubmed: 27989777
Front Behav Neurosci. 2016 Nov 15;10:220
pubmed: 27895564
CNS Spectr. 2014 Jun;19(3):225-30
pubmed: 23663386
JAMA Psychiatry. 2013 Jul;70(7):727-39
pubmed: 23636842
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neuropsychopharmacology. 2018 Nov;43(12):2445-2451
pubmed: 29795403
Cereb Cortex. 2008 Jun;18(6):1475-84
pubmed: 17940084
Hum Brain Mapp. 2019 May;40(7):2017-2032
pubmed: 30318709
Exp Clin Psychopharmacol. 2020 Dec;28(6):649-658
pubmed: 31886700
Neuropsychopharmacology. 2013 May;38(6):1085-93
pubmed: 23303067
Hum Brain Mapp. 2005 May;25(1):6-21
pubmed: 15846823
Addiction. 2007 Apr;102(4):579-86
pubmed: 17309540
Brain Sci. 2018 Jan 04;8(1):
pubmed: 29300304
Psychol Bull. 1996 Jul;120(1):3-24
pubmed: 8711015
Drug Alcohol Depend. 2004 Sep 6;75(3):225-31
pubmed: 15283943
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Arch Gen Psychiatry. 2010 Jun;67(6):632-44
pubmed: 20530013
Neuroimage. 2011 Aug 1;57(3):1221-33
pubmed: 21609772
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9453-8
pubmed: 19478067
Psychopharmacology (Berl). 2012 Jan;219(2):511-8
pubmed: 21384105
Biol Psychiatry. 1998 Dec 15;44(12):1219-28
pubmed: 9861465
Brain Imaging Behav. 2020 Apr;14(2):586-598
pubmed: 31115861
Psychol Addict Behav. 2013 Mar;27(1):71-80
pubmed: 22905898
J Cogn Neurosci. 2000 Nov;12(6):988-1000
pubmed: 11177419
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
Drug Alcohol Depend. 2008 Sep 1;97(1-2):1-20
pubmed: 18479844
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
N Engl J Med. 2016 Jan 28;374(4):363-71
pubmed: 26816013

Auteurs

Laura Murray (L)

McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, United States. Electronic address: lmurray@mclean.harvard.edu.

Julia C Welsh (JC)

McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.

Chase G Johnson (CG)

The Center for Anxiety and Related Disorders, Boston University, 900 Commonwealth Avenue, 2nd Floor, Boston, MA 02215, United States.

Roselinde H Kaiser (RH)

Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, United States.

Todd J Farchione (TJ)

The Center for Anxiety and Related Disorders, Boston University, 900 Commonwealth Avenue, 2nd Floor, Boston, MA 02215, United States.

Amy C Janes (AC)

Cognitive and Pharmacological Neuroimaging Unit, National Institute on Drug Abuse, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe limbique › Gyrus du cingulum › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Temps de réaction › Alcohol- and non-alcohol-related interference:...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Test de Stroop › Alcohol- and non-alcohol-related interference:...