Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides
MHC-II
Vimentin
cancer
carbamylation
post-translation modifications
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
02
2022
accepted:
14
03
2022
entrez:
25
4
2022
pubmed:
26
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Homocitrullination is the post translation modification (PTM) of the amino acid lysine to homocitrulline also referred to as carbamylation. This PTM has mainly been studied in relation to autoimmune diseases including rheumatoid arthritis. Homocitrullination of lysines alters their charge which can lead to generation of neoepitopes that are differentially presented by MHC-II and induce modification-specific immune responses. Homocitrullination is often considered a process which triggers autoimmune disease by bypassing self-tolerance however, we suggest that homocitrullination may also have an alternative role in immune responses including protection against cancer. Here we demonstrate that immune responses to homocitrullinated peptides from three different proteins can be induced
Identifiants
pubmed: 35464453
doi: 10.3389/fimmu.2022.873947
pmc: PMC9028767
doi:
Substances chimiques
Peptides
0
Vaccines
0
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
873947Informations de copyright
Copyright © 2022 Cook, Xue, Atabani, Symonds, Al Omari, Daniels, Shah, Choudhury, Weston, Metheringham, Brentville and Durrant.
Déclaration de conflit d'intérêts
KC, WX, VB, and LD have ownership interest in a patent WO2020053304A2. LD is a director and shareholder in Scancell Ltd. All authors are employees of Scancell Ltd. This study received funding from Scancell Ltd. The funder had the following involvement with the study: design, data collection and analysis, decision to publish and preparation of the manuscript.
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