New Methodology for Accurate Determination of Molecular Co-localization at the Nanoscale.

Spectrometry, Mass, Secondary Ion

Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
10 05 2022
Historique:
pubmed: 26 4 2022
medline: 12 5 2022
entrez: 25 4 2022
Statut: ppublish

Résumé

A new methodology using nanoparticle projectile secondary ion mass spectrometry was developed to identify statistically significant co-localization of tagged proteins versus random aggregations at the nanoscale. The custom instrument was run in the unique event-by-event bombardment detection mode with 1040 keV Au

Identifiants

DOI: 10.1021/acs.langmuir.2c00217 PMID: 35465673
pubmed: 35465673
doi: 10.1021/acs.langmuir.2c00217
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5626-5632

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM123757
Pays : United States

Auteurs

D S Verkhoturov (DS)

Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.

M J Eller (MJ)

Department of Chemistry and Biochemistry, California State University, Northridge, California 91330, United States.
ORCID: 0000-0002-9069-2180

Y D Han (YD)

Mayo Clinic, 200 1st Street SW St-11-14, Rochester, Minnesota 55905, United States.

B Crulhas (B)

Mayo Clinic, 200 1st Street SW St-11-14, Rochester, Minnesota 55905, United States.

S V Verkhoturov (SV)

Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.

A Revzin (A)

Mayo Clinic, 200 1st Street SW St-11-14, Rochester, Minnesota 55905, United States.

E A Schweikert (EA)

Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
ORCID: 0000-0003-3964-7998

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse d'ions secondaires › New Methodology for Accurate Determination of...