New insights into tuft cell formation: Implications for structure-function relationships.

Cell Differentiation Intestinal Mucosa / metabolism Structure-Activity Relationship

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
06 2022
Historique:
received: 30 12 2021
revised: 18 03 2022
accepted: 24 03 2022
pubmed: 26 4 2022
medline: 14 6 2022
entrez: 25 4 2022
Statut: ppublish

Résumé

Tuft cells are sentinel chemosensory cells that monitor the lumen of hollow organs for noxious or infectious stimuli and respond with disease- and tissue-specific effectors. The discovery of critical tuft cell functions in intestinal type 2 immune responses and airway defense has sparked interest in the formation and function of this architecturally unique cell type. Recent advances in single-cell transcriptomics and computational biology allow for new insights into the genetics and environmental cues underlying tuft cell formation and maturation. Here, we summarize the most recent research on tuft cell development and function in various disease states and organ systems.

Identifiants

DOI: 10.1016/j.ceb.2022.102082 PMID: 35468541 PMC: PMC9187611
pubmed: 35468541
pii: S0955-0674(22)00028-X
doi: 10.1016/j.ceb.2022.102082
pmc: PMC9187611
mid: NIHMS1794948
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

102082

Subventions

Organisme : NIDDK NIH HHS
ID : F32 DK121476
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM142709
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC018237
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145848
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197687
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI026918
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128903
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

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Auteurs

Claire E O'Leary (CE)

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Zhibo Ma (Z)

Gene Expression Laboratory, The Salk Institute for Biological Studies, San Diego, CA, USA.

Taylor Culpepper (T)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Sammy Weiser Novak (SW)

Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies, San Diego, CA, USA.

Kathleen E DelGiorno (KE)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: kathleen.delgiorno@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › New insights into tuft cell formation:...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › New insights into tuft cell formation:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › New insights into tuft cell formation:...