The role of intrinsic fines in the performance change of expired lactose carriers for DPI applications.
Dispersion
Inhalation
Interactive blend
Powder rheometer
Respiratory
Stability
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
25
01
2022
revised:
18
04
2022
accepted:
18
04
2022
pubmed:
27
4
2022
medline:
26
5
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Dry powder inhalation offers a well-established administration route for either local or systemic drug delivery. Lactose-based powder blends still build the basis of respiratory drug delivery, despite of numerous emerging formulation approaches. The amount of fine lactose excipients, either extrinsic or intrinsic, crucially influences the aerodynamic performance of the corresponding blend. This study highlights the role of intrinsic fines as a fundamental performance affecting parameter during storage and expiry of lactose carrier bulk. We showed that intrinsic fines play an inferior role after expiring compared to fresh batches. If strongly adhering or even merged fines regain their mobility and contribute to the dispersion (by removal and re-addition), it will significantly enhance drug delivery. Furthermore, we provide evidence for decreased mobility of intrinsic fines caused by humidity (e.g., during inappropriate storage) resulting in decreased powder fluidisation.
Identifiants
pubmed: 35470067
pii: S0939-6411(22)00078-9
doi: 10.1016/j.ejpb.2022.04.006
pii:
doi:
Substances chimiques
Aerosols
0
Drug Carriers
0
Excipients
0
Powders
0
Lactose
J2B2A4N98G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-12Informations de copyright
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