Effects of prenatal and lactational exposure to iodoacetic acid on the F1 generation of mice†.
Disinfection byproducts
endocrine-disrupting chemicals
fertility
iodoacetic acid
ovary
steroidogenesis
Journal
Biology of reproduction
ISSN: 1529-7268
Titre abrégé: Biol Reprod
Pays: United States
ID NLM: 0207224
Informations de publication
Date de publication:
09 08 2022
09 08 2022
Historique:
received:
21
01
2022
revised:
07
03
2022
accepted:
15
04
2022
pubmed:
27
4
2022
medline:
19
8
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Water disinfection can generate water disinfection byproducts (DBPs). Iodoacetic acid (IAA) is one DBP, and it has been shown to be an ovarian toxicant in vitro and in vivo. However, it is unknown if prenatal and lactational exposure to IAA affects reproductive outcomes in female offspring. This study tested the hypothesis that prenatal and lactational exposure to IAA adversely affects reproductive parameters in F1 female offspring. Adult female CD-1 mice were dosed with water (control) or IAA (10, 100, and 500 mg/L) in the drinking water for 35 days and then mated with unexposed males. IAA exposure continued throughout gestation. Dams delivered naturally, and pups were continuously exposed to IAA through lactation until postnatal day (PND) 21. Female pups were euthanized on PND 21 and subjected to measurements of anogenital distance, ovarian weight, and vaginal opening. Ovaries were subjected to histological analysis. In addition, sera were collected to measure reproductive hormone levels. IAA exposure decreased vaginal opening rate, increased the absolute weight of the ovaries, increased anogenital index, and decreased the percentage of atretic follicles in female pups compared to control. IAA exposure caused a borderline decrease in the levels of progesterone and follicle-stimulating hormone (FSH) and increased levels of testosterone in female pups compared to control. Collectively, these data show that prenatal and lactational exposure to IAA in drinking water affects vaginal opening, anogenital index, the weight of the ovaries, the percentage of atretic follicles, and hormone levels in the F1 generation in mice.
Identifiants
pubmed: 35470848
pii: 6574077
doi: 10.1093/biolre/ioac079
pmc: PMC9382386
doi:
Substances chimiques
Drinking Water
0
Hormones
0
Iodoacetic Acid
WF5188V710
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
650-663Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES028963
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007326
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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