Possible cytoprotective mechanisms of oxytocin against 5-fluorouracil-induced gastrointestinal mucositis.
5-fluorouracil
Chemotherapy
Cytokine
Mucositis
Oxytocin
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
03
02
2022
accepted:
16
03
2022
revised:
15
03
2022
pubmed:
28
4
2022
medline:
10
6
2022
entrez:
27
4
2022
Statut:
ppublish
Résumé
Gastrointestinal mucositis is a common and dose-limiting side effect characterized by ulcerative lesions in the mucosa of the digestive tract in patients receiving anticancer drugs such as 5-fluorouracil (5-FU), a potent antineoplastic drug. Several protocols have reported the efficacy of therapeutic interventions to prevent this side effect, although complete success has not yet been achieved and mucositis remains one of the most serious complications associated with 5-FU therapy. Oxytocin, a well-known antistress agent, has been reported to have comparable effects to ranitidine. Previous studies have shown that oxytocin inhibits gastric acid secretion and the expression of proinflammatory cytokines in rats. If oxytocin can reduce stress-induced ulcers via antioxidant, antiapoptotic, and anti-inflammatory pathways, then it may have a dose-dependent effect on gastrointestinal mucositis caused by 5-FU.
Identifiants
pubmed: 35474056
doi: 10.1007/s11033-022-07384-3
pii: 10.1007/s11033-022-07384-3
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Oxytocin
50-56-6
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4055-4059Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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