Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections.
CD8 T cells
non-severe SARS-CoV-2 infection
type 1 interferon
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
15 03 2022
15 03 2022
Historique:
received:
14
04
2021
revised:
22
11
2021
accepted:
09
02
2022
entrez:
27
4
2022
pubmed:
28
4
2022
medline:
29
4
2022
Statut:
epublish
Résumé
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses. These peak by the time the virus is first detected and sometimes precede virus detection. Cell proliferation is most evident in CD8 T cells and associated with specific expansion of SARS-CoV-2-reactive TCRs, in contrast to virus-specific antibodies, which lag by 1-2 weeks. Our data support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines.
Identifiants
pubmed: 35474751
doi: 10.1016/j.xcrm.2022.100557
pii: S2666-3791(22)00064-7
pmc: PMC8895494
doi:
Substances chimiques
Interferon Type I
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100557Subventions
Organisme : British Heart Foundation
ID : FS/CRTF/21/24143
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20060
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/35/34374
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N007727/1
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR134607
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R02622X/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/20/2/34841
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W020610/1
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-044-0001-RG-SWADL
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019553/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : AA/18/6/34223
Pays : United Kingdom
Organisme : Department of Health
ID : DRF-2018-11-ST2-004
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214191/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V036939/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207511/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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