Cross Brain-Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors.
Brain-gut axis
Depression
Endurance exercise
Leucine
LncRNAs
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
11
02
2022
accepted:
09
04
2022
pubmed:
28
4
2022
medline:
9
6
2022
entrez:
27
4
2022
Statut:
ppublish
Résumé
Depression is a frequent mood disorder that might impair the brain-gut axis. In this study, we divided 30 mice into five groups: untreated mice, mice with depression-like behaviors, mice with depression-like behaviors treated with consumed leucine, mice with depression-like behaviors treated with exercise training, mice with depression-like behaviors treated with exercise training along with consumed leucine. According to artificial intelligence biological analysis, we found some mediators such as lncRNAs profile and Kdr/Vegfα/Pten/Bdnf interactions network in the hippocampus region and ileum tissue which could be decisive molecules in the brain-gut axis. Moreover, KDR as a principal cutpoint protein in the network was identified as the pharmaceutical approach for major depressive ameliorating based on pharmacophore modeling and molecular docking outcomes. Furthermore, we indicated that the mRNA and protein level of the Pten enhanced and Vegfα/Kdr/Bdnf mRNAs, as well as the protein level of KDR, decreased in mice with depression-like behaviors. Moreover, exercise and leucine ameliorated the brain-gut axis in mice with depression-like behaviors. Exercise and leucine regulated the lncRNAs network in the hippocampus and ileum of mice with depression-like behaviors. We suggest that the lncRNAs profiles could be considered as diagnosis and prognosis biomarkers, and exercise + leucine might be a practical approach to improve depression.
Identifiants
pubmed: 35476290
doi: 10.1007/s12035-022-02835-1
pii: 10.1007/s12035-022-02835-1
pmc: PMC9045027
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
RNA, Long Noncoding
0
RNA, Messenger
0
Leucine
GMW67QNF9C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4106-4123Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Neurobiol Stress. 2020 Mar 20;12:100216
pubmed: 32258258
Nat Rev Mol Cell Biol. 2013 Nov;14(11):699-712
pubmed: 24105322
Prog Brain Res. 2000;122:187-94
pubmed: 10737058
Front Psychiatry. 2018 Jul 19;9:305
pubmed: 30072923
Am J Prev Med. 2013 Nov;45(5):649-57
pubmed: 24139780
Methods Mol Biol. 2017;1561:235-254
pubmed: 28236242
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Clin Chim Acta. 2006 Jan;363(1-2):187-96
pubmed: 16126188
Child Adolesc Psychiatry Ment Health. 2011 May 14;5:16
pubmed: 21569581
J Am Coll Health. 2009 Jan-Feb;57(4):427-36
pubmed: 19114382
Behav Brain Res. 2014 Aug 15;270:339-48
pubmed: 24875770
Pflugers Arch. 2019 Mar;471(3):479-489
pubmed: 30656407
Exp Mol Med. 2014 Feb 07;46:e75
pubmed: 24503708
Methods Mol Biol. 2015;1263:243-50
pubmed: 25618350
Nucleic Acids Res. 2021 Jan 8;49(D1):D1388-D1395
pubmed: 33151290
Semin Cell Dev Biol. 2018 May;77:133-143
pubmed: 29051054
Psychosom Med. 2019 Apr;81(3):265-280
pubmed: 30720698
Cells. 2020 Apr 22;9(4):
pubmed: 32331397
J Proteome Res. 2016 Sep 2;15(9):3126-38
pubmed: 27482843
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Brain Behav Immun. 2015 Aug;48:165-73
pubmed: 25866195
Behav Res Ther. 2018 Mar;102:25-35
pubmed: 29291584
BMJ Open. 2019 Sep 4;9(9):e028295
pubmed: 31488474
Mucosal Immunol. 2019 Mar;12(2):468-478
pubmed: 30542111
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
Nature. 2008 Oct 16;455(7215):894-902
pubmed: 18923511
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:99-109
pubmed: 28396255
Biomed Res Int. 2018 Jul 3;2018:8249563
pubmed: 30065945
Gut Microbes. 2014 May-Jun;5(3):390-6
pubmed: 24690880
PLoS One. 2020 Feb 20;15(2):e0229288
pubmed: 32078638
J Histochem Cytochem. 2004 Apr;52(4):509-16
pubmed: 15034002
Psychol Med. 2021 Jan 13;:1-9
pubmed: 33436120
Nucleic Acids Res. 2021 Jan 8;49(D1):D437-D451
pubmed: 33211854
Nutr Metab (Lond). 2018 Aug 29;15:59
pubmed: 30181762
Nutr J. 2021 Jan 29;20(1):11
pubmed: 33514378
Cell. 2007 Oct 19;131(2):391-404
pubmed: 17956738
BMC Public Health. 2020 Aug 18;20(1):1255
pubmed: 32811468
Front Mol Neurosci. 2022 Jan 11;14:745437
pubmed: 35087377
Acta Histochem. 2022 Feb;124(2):151844
pubmed: 35045377
Sci Rep. 2017 Mar 03;7:42717
pubmed: 28256516
Antioxidants (Basel). 2019 Sep 06;8(9):
pubmed: 31489956
Exp Gerontol. 1996 May-Jun;31(3):387-92
pubmed: 9415121
Arch Gen Psychiatry. 2005 Jun;62(6):629-40
pubmed: 15939840
Disabil Rehabil. 2015;37(16):1490-5
pubmed: 25342564
J Neurosci. 2004 Feb 11;24(6):1330-9
pubmed: 14960604
Biol Psychiatry. 2014 Oct 1;76(7):510-2
pubmed: 25201436
Nat Neurosci. 2015 Feb;18(2):199-209
pubmed: 25599223
Front Pharmacol. 2021 Jun 28;12:705325
pubmed: 34262463
Biol Psychiatry. 2019 Mar 15;85(6):487-497
pubmed: 30528746
J Psychopharmacol. 2007 Jul;21(5):538-44
pubmed: 17446201
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612
pubmed: 33237311
Trends Mol Med. 2014 Sep;20(9):509-18
pubmed: 24956966
Evid Based Complement Alternat Med. 2012;2012:809653
pubmed: 22969831
Transl Psychiatry. 2021 Mar 26;11(1):185
pubmed: 33771972
Adv Exp Med Biol. 2014;817:255-76
pubmed: 24997038
Front Neurosci. 2020 Mar 03;14:129
pubmed: 32194368
Nucleic Acids Res. 2020 Jan 8;48(D1):D118-D126
pubmed: 31713618
J Nutr. 2005 Jun;135(6 Suppl):1539S-46S
pubmed: 15930466
Psychopharmacology (Berl). 2004 Jan;171(3):286-97
pubmed: 12955284
Nucleic Acids Res. 2021 Jul 2;49(W1):W317-W325
pubmed: 34086934
Psychoneuroendocrinology. 2016 Jan;63:217-27
pubmed: 26479188
N Engl J Med. 2016 Dec 15;375(24):2369-2379
pubmed: 27974040