Microstructure, mechanical properties and osseointegration ability of Ta-20Zr alloy used as dental implant material.
dental implant material
elastic modulus
immune response
osseointegration ability
Journal
Biomedical materials (Bristol, England)
ISSN: 1748-605X
Titre abrégé: Biomed Mater
Pays: England
ID NLM: 101285195
Informations de publication
Date de publication:
11 05 2022
11 05 2022
Historique:
received:
08
01
2022
accepted:
27
04
2022
pubmed:
28
4
2022
medline:
14
5
2022
entrez:
27
4
2022
Statut:
epublish
Résumé
The aim of this study was to evaluate the application prospect of a tantalum (Ta) and zirconium (Zr) alloy as a dental implant material. The Ta-20Zr (wt.%) alloy was prepared by powder metallurgy, and its microstructure and mechanical properties were analyzed by standard techniques. The effect of Ta-20Zr alloy on inflammation, bone remodeling and osseointegration was analyzed in rat and rabbit models by biochemical, histological and imaging tests. The Ta-20Zr alloy showed excellent mechanical compatibility with the bone tissue on account of similar elastic modulus (49.2 GPa), thereby avoiding the 'stress shielding effect'. Furthermore, Ta-20Zr alloy enhanced the inflammatory response by promoting secretion of interleukin-6 (IL-6) and IL-10, and facilitated the balance between the M1/M2 macrophage phenotypes. Finally, Ta-20Zr also showed excellent osseointegration and osteogenic ability without any systemic side effects, making it an ideal dental implant material.
Identifiants
pubmed: 35477054
doi: 10.1088/1748-605X/ac6b05
doi:
Substances chimiques
Alloys
0
Dental Implants
0
Dental Materials
0
Tantalum
6424HBN274
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 IOP Publishing Ltd.