A novel anti-lung cancer agent inhibits proliferation and epithelial-mesenchymal transition.
Chalcone-1,3,4-thiadiazole
NCI-H460 cells
c-Met inhibitor
epithelial–mesenchymal transition
synthesize
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
30
4
2022
Statut:
ppublish
Résumé
To synthesize a novel chalcone-1,3,4-thiadiazole hybrid and investigate its anticancer effects against NCI-H460 cells. ( Compound ZW97 selectively inhibited cell proliferation against lung cancer cell lines NCI-H460, HCC-44 and NCI-H3122 with IC Compound ZW97 is a potential c-Met inhibitor that might be a promising agent to treat lung cancer by inhibiting the epithelial-mesenchymal transition process.
Identifiants
pubmed: 35477254
doi: 10.1177/03000605211066300
pmc: PMC9087257
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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