Design, Synthesis, and Biological Evaluation of 4-Arylamino Pyrimidine Derivatives as FAK Inhibitors and Tumor Radiotracers.

Antineoplastic Agents / chemistry Cell Line, Tumor Cell Proliferation Drug Design Drug Screening Assays, Antitumor Focal Adhesion Protein-Tyrosine Kinases / metabolism Humans Molecular Docking Simulation Neoplasms / diagnostic imaging Protein Kinase Inhibitors / chemistry Structure-Activity Relationship
18F labeled FAK inhibitor focal adhesion kinase (FAK) molecular docking tumor radiotracers

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
04 07 2022
Historique:
pubmed: 29 4 2022
medline: 8 7 2022
entrez: 28 4 2022
Statut: ppublish

Résumé

Focal adhesion kinase (FAK) is considered a promising target for the diagnosis and treatment of cancer. In this work, a series of

Identifiants

DOI: 10.1021/acs.molpharmaceut.2c00180 PMID: 35481371
pubmed: 35481371
doi: 10.1021/acs.molpharmaceut.2c00180
doi:

Substances chimiques

Antineoplastic Agents 0
Protein Kinase Inhibitors 0
Focal Adhesion Protein-Tyrosine Kinases EC 2.7.10.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2471-2482

Auteurs

Ye Li (Y)

College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
ORCID: 0000-0001-8407-2869

Yueheng Qi (Y)

College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
ORCID: 0000-0001-8837-0767

Yu Fang (Y)

College of Chemistry and Chemical Engineering, Anyang Normal University, No. 436 Xian'ge Road, Anyang 455000, Henan Province, China.

Hang Gao (H)

College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.

Huabei Zhang (H)

College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Focal adhesion protein-tyrosine kinases › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Tumeurs › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Design, Synthesis, and Biological Evaluation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, Synthesis, and Biological Evaluation...