Misdiagnosis of narcolepsy caused by a false-positive orexin-A/hypocretin-1 enzyme immune assay.
hypocretin.
narcolepsy
orexin
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
pubmed:
29
4
2022
medline:
3
8
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
The diagnosis of narcolepsy is based on clinical history, sleep studies, and, in some cases, cerebrospinal fluid orexin-A/hypocretin-1 measurement. The gold standard for orexin measurement is the radioimmunoassay but other commercial kits are also available, such as the enzyme immune assay (EIA). The specificity of orexin EIA in humans is unknown. We report four cases where orexin levels were measured by EIA and resulted in false positives and the misdiagnosis of narcolepsy. Therefore, orexin EIA measurement should be strongly discouraged in a clinical setting. Sarkanen T, Sved G, Juujärvi M, Alakuijala A, Partinen M. Misdiagnosis of narcolepsy caused by a false-positive orexin-A/hypocretin-1 enzyme immune assay.
Identifiants
pubmed: 35481446
pii: jcsm.10014
doi: 10.5664/jcsm.10014
pmc: PMC9340599
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Neuropeptides
0
Orexins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2075-2078Informations de copyright
© 2022 American Academy of Sleep Medicine.
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