Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans.
LDL
arabinoxylan
bile acid
cholesterol
cholesterol ester
dietary fiber
ferulic acid
fiber
inulin
lipidmoics
metabolomics
metagenome
microbiome
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
08 06 2022
08 06 2022
Historique:
received:
03
11
2021
revised:
19
01
2022
accepted:
25
03
2022
pubmed:
29
4
2022
medline:
14
6
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multiomic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel, and clinical measurements on healthy and insulin-resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose, there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation and the mechanisms behind fiber-induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome.
Identifiants
pubmed: 35483363
pii: S1931-3128(22)00166-4
doi: 10.1016/j.chom.2022.03.036
pmc: PMC9187607
mid: NIHMS1796883
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Dietary Fiber
0
Inulin
9005-80-5
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
848-862.e7Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010232
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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