In vitro effects of the 4-[(10H-phenothiazin-10-yl)methyl]-N-hydroxybenzamide on Giardia intestinalis trophozoites.
Cytokinesis
Cytoskeleton
Electron microscopy
Giardia intestinalis
Lysine deacetylase inhibitor
Proliferation
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
03
01
2022
revised:
19
04
2022
accepted:
22
04
2022
pubmed:
29
4
2022
medline:
15
6
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Giardiasis is an intestinal disease caused by the parasite protozoan Giardia intestinalis. For more than five decades, the treatment of this disease has been based on compounds such as nitroimidazoles and benzimidazoles. The parasite's adverse effects and therapeutic failure are largely recognized. Therefore, it is necessary to develop new forms of chemotherapy treatment against giardiasis. Lysine deacetylases (KDACs), which remove an acetyl group from lysine residues in histone and non-histone proteins as tubulin, are found in the Giardia genome and can become an interesting option for giardiasis treatment. In the present study, we evaluated the effects of 4-[(10H-phenothiazin-10-yl)methyl]-N-hydroxybenzamide, a new class I/II KDAC inhibitor, on G. intestinalis growth, cytoskeleton, and ultrastructure organization. This compound decreased parasite proliferation and viability and displayed an IC
Identifiants
pubmed: 35483428
pii: S0001-706X(22)00176-0
doi: 10.1016/j.actatropica.2022.106484
pii:
doi:
Substances chimiques
Lysine
K3Z4F929H6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106484Informations de copyright
Copyright © 2022. Published by Elsevier B.V.