Protein X0P338, a GntR-type pleiotropic regulator for morphological differentiation and secondary metabolites production in Streptomyces diastatochromogenes 1628.
GntR
S. diastatochromogenes 1628
morphological differentiation
toyocamycin
Journal
Journal of basic microbiology
ISSN: 1521-4028
Titre abrégé: J Basic Microbiol
Pays: Germany
ID NLM: 8503885
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
08
04
2022
received:
12
02
2022
accepted:
15
04
2022
pubmed:
30
4
2022
medline:
7
7
2022
entrez:
29
4
2022
Statut:
ppublish
Résumé
The nucleoside antibiotic, toyocamycin (TM) exhibits excellent potent activity against several phytopathogenic fungi. Despite its importance, little is known about key factors regulating TM biosynthesis and morphological differentiation in Streptomyces diastatochromogenes 1628. Based on proteomics data obtained from the analysis between wild-type (WT) S. diastatochromogenes 1628 strain and mutant strain 1628-T62 having a low yield of TM, we observed that the differentially expressed protein, X0P338, which was proposed to be a regulator of the GntR-family, exhibited a higher expression level in S. diastatochromogenes 1628. Therefore, in this study, to explore whether protein X0P338 was involved in morphological differentiation and biosynthesis of secondary metabolites, especially TM, the gene called the gntR
Identifiants
pubmed: 35485240
doi: 10.1002/jobm.202200086
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Toyocamycin
L7995C4D7F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
788-800Informations de copyright
© 2022 Wiley-VCH GmbH.
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