Failure of stereotactic core needle biopsy in women recalled for suspicious calcifications at screening mammography: frequency, causes, and final outcome in a multi-institutional, observational follow-up study.


Journal

European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774

Informations de publication

Date de publication:
Nov 2022
Historique:
received: 16 12 2021
accepted: 08 04 2022
revised: 20 03 2022
pubmed: 30 4 2022
medline: 19 11 2022
entrez: 29 4 2022
Statut: ppublish

Résumé

We determined the failure rate of stereotactic core needle biopsy (SCNB) and its causes and final outcome in women recalled for calcifications at screening mammography. We included a consecutive series of 624,039 screens obtained in a Dutch screening region between January 2009 and July 2019. Radiology reports and pathology results were obtained of all recalled women during 2-year follow-up. A total of 3495 women (19.6% of 17,809 recalls) were recalled for suspicious calcifications. SCNB was indicated in 2818 women, of whom 12 had incomplete follow-up and another 12 women refused biopsy. DCIS or invasive cancer was diagnosed in 880 of the remaining 2794 women (31.5%). SCNB failed in 62 women (2.2%, 36/2794). These failures were mainly due to a too posterior (n = 30) or too superficial location (n = 17) of the calcifications or calcifications too faint for biopsy (n = 13). Of these 62 women, 10 underwent surgical biopsy, yielding one DCIS (intermediate grade) and two invasive cancers (one intermediate grade and one high grade) and another two women were diagnosed with DCIS (both high grade) at follow-up. Thus, the malignancy rate after SCNB failure was 8.1% (5/62). Calcifications were depicted neither at SCNB specimen radiography nor at pathology in 16 women after (repeated) SCNB (0.6%, 31/2732). None of them proved to have breast cancer at 2-year follow-up. The failure rate of SCNB for suspicious calcifications is low but close surveillance is warranted, as breast cancer may be present in up to 8% of these women. • The failure rate of stereotactic core needle biopsy (SCNB) for calcifications recalled at screening mammography was 2.2%. • Failures were mainly due to calcifications that could not be reached by SCNB or calcifications too faint for biopsy. • The management after failed SCNB was various. At least, close surveillance with a low threshold for surgical biopsy is recommended as breast cancer may be present in up to 8% of women with SCNB failure.

Identifiants

pubmed: 35486173
doi: 10.1007/s00330-022-08806-3
pii: 10.1007/s00330-022-08806-3
doi:

Types de publication

Multicenter Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7420-7429

Informations de copyright

© 2022. The Author(s), under exclusive licence to European Society of Radiology.

Références

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Auteurs

Lucien E M Duijm (LEM)

Department of Radiology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands. lemduijm@hotmail.com.

Luc J A Strobbe (LJA)

Department of Surgical Oncology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.

Vivian van Breest Smallenburg (V)

Department of Radiology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, 's-Hertogenbosch, The Netherlands.

Willem Vreuls (W)

Department of Pathology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.

Thom Boerman (T)

Department of Pathology, PAMM Laboratories, De Run 6250, 5504 DL, Veldhoven, The Netherlands.

Hermen C van Beek (HC)

Department of Radiology, Maxima Medical Center, De Run 4600, 5504 DB, Veldhoven, The Netherlands.

Clemence L Op de Coul-Froger (CL)

Department of Radiology, Bernhoven Hospital, Nistelrodeseweg 10, 5406 PT, Uden, The Netherlands.

Wikke Setz-Pels (W)

Department of Radiology, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

Adri C Voogd (AC)

Department of Epidemiology, Maastricht University Medical Center, P Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

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