Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.
cystic fibrosis
inflammation
microbiome
mucins
mucus obstruction
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
30
4
2022
medline:
4
8
2022
entrez:
29
4
2022
Statut:
ppublish
Résumé
The dynamics describing the vicious cycle characteristic of cystic fibrosis (CF) lung disease, initiated by stagnant mucus and perpetuated by infection and inflammation, remain unclear. Here we determine the effect of the CF airway milieu, with persistent mucoobstruction, resident pathogens, and inflammation, on the mucin quantity and quality that govern lung disease pathogenesis and progression. The concentrations of MUC5AC and MUC5B were measured and characterized in sputum samples from subjects with CF (
Identifiants
pubmed: 35486871
doi: 10.1165/rcmb.2021-0359OC
pmc: PMC9348562
doi:
Substances chimiques
Mucin 5AC
0
Mucin-5B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
253-265Commentaires et corrections
Type : CommentIn
Références
PLoS One. 2014 Feb 18;9(2):e87681
pubmed: 24558372
Glycobiology. 2014 May;24(5):402-6
pubmed: 24653214
Glycobiology. 2007 Jul;17(7):698-712
pubmed: 17392389
Respir Res. 2009 Jul 06;10:63
pubmed: 19580650
Am J Respir Crit Care Med. 2019 Jan 15;199(2):171-180
pubmed: 30212240
Lancet Respir Med. 2021 Nov;9(11):1241-1254
pubmed: 34058148
J Biol Chem. 2007 Mar 23;282(12):9127-42
pubmed: 17264077
Chest. 2018 Aug;154(2):370-377
pubmed: 29559310
Annu Rev Med. 2007;58:157-70
pubmed: 17217330
J Exp Biol. 1992 Nov;172:245-66
pubmed: 1337094
J Cyst Fibros. 2014 May;13(3):260-6
pubmed: 24332705
Science. 2012 Aug 24;337(6097):937-41
pubmed: 22923574
Mediators Inflamm. 2015;2015:293053
pubmed: 26185359
J Cyst Fibros. 2015 May;14(3):324-33
pubmed: 25286826
Methods Mol Biol. 2018;1841:3-10
pubmed: 30259475
Annu Rev Physiol. 2008;70:459-86
pubmed: 17850213
Biochem J. 2002 Feb 1;361(Pt 3):537-46
pubmed: 11802783
J Allergy Clin Immunol. 2018 Jan;141(1):117-127
pubmed: 28506850
Eur Respir J. 2018 Jul 11;52(1):
pubmed: 29946004
Science. 1989 Sep 8;245(4922):1066-73
pubmed: 2475911
J Clin Invest. 2014 Jul;124(7):3047-60
pubmed: 24892808
Am J Respir Crit Care Med. 2020 Mar 15;201(6):661-670
pubmed: 31765597
Nature. 1991 Jul 4;352(6330):70-3
pubmed: 1712081
Glycobiology. 2015 Dec;25(12):1323-4
pubmed: 26543186
Mucosal Immunol. 2016 Jul;9(4):1039-1050
pubmed: 26555707
Infect Immun. 2011 Aug;79(8):3438-44
pubmed: 21646446
Sci Transl Med. 2015 Feb 25;7(276):276ra27
pubmed: 25717100
Eur Respir J. 2018 Dec 6;52(6):
pubmed: 30361244
Biochem J. 2005 May 1;387(Pt 3):911-9
pubmed: 15563276
Ann Am Thorac Soc. 2015 May;12(5):701-7
pubmed: 25679336
J Proteome Res. 2016 Sep 2;15(9):2969-80
pubmed: 27432553
PLoS Pathog. 2018 Jan 18;14(1):e1006798
pubmed: 29346420
N Engl J Med. 2013 May 23;368(21):1963-70
pubmed: 23692169
N Engl J Med. 2018 Oct 25;379(17):1599-1611
pubmed: 30334693
J Biol Chem. 2008 Oct 31;283(44):30385-400
pubmed: 18725413
N Engl J Med. 2017 Sep 7;377(10):911-922
pubmed: 28877023
Nat Med. 2017 Jun;23(6):681-691
pubmed: 28459437
Am J Physiol. 1999 May;276(5):L835-43
pubmed: 10330040
PLoS Pathog. 2016 Aug 22;12(8):e1005846
pubmed: 27548479
Pflugers Arch. 2001;443 Suppl 1:S50-4
pubmed: 11845303
Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12501-12506
pubmed: 30420506
Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L824-34
pubmed: 15194565
Am J Respir Crit Care Med. 2008 May 1;177(9):995-1001
pubmed: 18263800
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):
pubmed: 34548396
Chest. 2017 Oct;152(4):771-779
pubmed: 28716644
J Med Microbiol. 2012 Dec;61(Pt 12):1644-1653
pubmed: 22918866
Mucosal Immunol. 2013 Mar;6(2):379-92
pubmed: 22929560
Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727
pubmed: 30352166
Arch Biochem Biophys. 1976 Nov;177(1):95-104
pubmed: 999298