Cancer-associated chromatin variants uncover the oncogenic role of transposable elements.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
10
12
2021
revised:
08
03
2022
accepted:
24
03
2022
pubmed:
30
4
2022
medline:
3
6
2022
entrez:
29
4
2022
Statut:
ppublish
Résumé
The vast array of cell states found across human tissue arises from chromatin variants, which correspond to segments of the genome, known as DNA elements, adopting a different chromatin state over cell state transitions. Oncogenesis stems from alterations to the chromatin states over DNA elements that result in cancer-associated chromatin variants. Here, we review how cancer-associated chromatin variants call attention to repetitive DNA elements, and guide the functional characterization of transposable elements to decode their role in oncogenesis. We further discuss prevailing opportunities in the study of repetitive DNA elements to move towards the 'complete cancer genome' goal for precision medicine in oncology.
Identifiants
pubmed: 35487182
pii: S0959-437X(22)00020-X
doi: 10.1016/j.gde.2022.101911
pii:
doi:
Substances chimiques
Chromatin
0
DNA Transposable Elements
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101911Subventions
Organisme : CIHR
ID : FRN-136963
Pays : Canada
Organisme : CIHR
ID : 153234
Pays : Canada
Organisme : CIHR
ID : 168933
Pays : Canada
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.