Improving organs-at-risk sparing for choroidal melanoma patients: A CT-based two-beam strategy in ocular proton therapy with a dedicated eyeline.

Choroid Neoplasms / radiotherapy Humans Melanoma / radiotherapy Organs at Risk Proton Therapy / methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted / methods Retrospective Studies Tomography, X-Ray Computed Uveal Neoplasms
Eyeline Imaging-based Multi-beam Proton therapy Uveal melanoma

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
06 2022
Historique:
received: 19 01 2022
revised: 20 04 2022
accepted: 21 04 2022
pubmed: 30 4 2022
medline: 9 6 2022
entrez: 29 4 2022
Statut: ppublish

Résumé

To investigate the potential clinical benefit of a two-beam arrangement technique using three-dimensional (3D) imaging of uveal melanoma (UM) patients treated with proton therapy and a dedicated eyeline. Retrospective CT-based treatment plans of 39 UM patients performed using a single beam (SB) were compared to plans with two beams (TB) optimized for better trade-offs in organs-at-risk sparing. The RBE-weighted prescribed dose was 60 Gy (D All strategies resulted in dosimetrically acceptable plans. A dose reduction to the anterior structures was achieved in 23/39 cases with the two-beam plans. D A two-beam strategy appears beneficial for posterior tumors abutting the optic nerve. This strategy might have a positive impact on the risk of ocular complications.

Identifiants

DOI: 10.1016/j.radonc.2022.04.021 PMID: 35487435
pubmed: 35487435
pii: S0167-8140(22)00227-4
doi: 10.1016/j.radonc.2022.04.021
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

173-181

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest This research was co-funded by the research program PROTONS4Vision (Grant NWO 14654), which is financed by the Netherlands Organization for Scientific Research (NWO), Technology Foundation STW, the Top consortium for Knowledge & Innovation (TKI-HTSM), and Varian Medical Systems Particle Therapy GmbH & Co. KG, Troisdorf, Germany.

Auteurs

Emmanuelle Fleury (E)

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands; Holland Proton Therapy Center, Delft, The Netherlands. Electronic address: e.fleury@erasmusmc.nl.

Petra Trnková (P)

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands; Medical University of Vienna, Department of Radiation Oncology, Vienna, Austria.

Caroline van Rij (C)

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands; Erasmus Medical Center, Department of Ophthalmology, Rotterdam, The Netherlands.

Myra Rodrigues (M)

Holland Proton Therapy Center, Delft, The Netherlands.

Yvonne Klaver (Y)

Holland Proton Therapy Center, Delft, The Netherlands.

Kees Spruijt (K)

Holland Proton Therapy Center, Delft, The Netherlands.

Nicole Naus (N)

Erasmus Medical Center, Department of Ophthalmology, Rotterdam, The Netherlands.

Andras Zolnay (A)

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands.

Jean-Philippe Pignol (JP)

Dalhousie University, Radiation Oncology, Halifax, Canada.

Emine Kiliç (E)

Erasmus Medical Center, Department of Ophthalmology, Rotterdam, The Netherlands; Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, The Netherlands.

Mischa S Hoogeman (MS)

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands; Holland Proton Therapy Center, Delft, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'oeil › Maladies de l'uvée › Tumeurs de l'uvée › Tumeurs de la choroïde › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Régions du corps › Organes à risque › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Protonthérapie › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Thérapie assistée par ordinateur › Radiothérapie assistée par ordinateur › Planification de radiothérapie assistée par ordinateur › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Improving organs-at-risk sparing for choroidal...
questionsmedicales.fr › Maladies de l'oeil › Maladies de l'uvée › Tumeurs de l'uvée › Improving organs-at-risk sparing for choroidal...