Synthesis, molecular docking, ADMET evaluation and

Animals Humans Chlorocebus aethiops Methotrexate / pharmacology Molecular Docking Simulation Phenytoin / pharmacology Vero Cells Structure-Activity Relationship Antineoplastic Agents / pharmacology Cell Line Rhabdomyosarcoma / drug therapy Drug Screening Assays, Antitumor Molecular Structure Cell Proliferation Cell Line, Tumor

Hydantoin antitumor activity hydrazone molecular docking toxicity

Journal

Journal of biomolecular structure & dynamics

ISSN: 1538-0254

Titre abrégé: J Biomol Struct Dyn

Pays: England

ID NLM: 8404176

Informations de publication

Date de publication:
Jul 2023

Historique:

medline: 12 6 2023

pubmed: 3 5 2022

entrez: 2 5 2022

Statut: ppublish

Résumé

Hydantoins comprise an important class of compounds which have long attracted attention due to their remarkable biological and pharmacological properties including antitumor and antiviral activities. As a continuation of our studies on hydantoins derivatives we report the successful synthesis of hydantoins derivatives. These synthesized compounds were evaluated for their cytotoxic activity against

Identifiants

DOI: 10.1080/07391102.2022.2069865 PMID: 35491728

pubmed: 35491728

doi: 10.1080/07391102.2022.2069865

doi:

Substances chimiques

Methotrexate YL5FZ2Y5U1

Phenytoin 6158TKW0C5

Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4592-4600

Auteurs

Walid Guerrab (W)

Laboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

Jihane Akachar (J)

Biotechnology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Morocco.

Meryem El Jemli (ME)

Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, Morocco.

Abdul-Malik Abudunia (AM)

Biotechnology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Morocco.

Rachida Ouaabou (R)

LICVEDDE/ERIDDECV (Research Team of Innovation and Sustainable Development & Expertise in Green Chemistry), Faculty of Science Semlalia, Cadi Ayyad University, Marrakesh, Morocco.

Katim Alaoui (K)

Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, Morocco.

Azeddine Ibrahimi (A)

Biotechnology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Morocco.

ORCID: 0000-0003-3226-3836

Youssef Ramli (Y)

Laboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

ORCID: 0000-0002-6885-5692

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Aminoptérine › Méthotrexate › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Hydantoïnes › Phénytoïne › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Myosarcome › Rhabdomyosarcome › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Synthesis, molecular docking, ADMET evaluation and

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis, molecular docking, ADMET evaluation and