Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study.
coronary flow reserve
fractional flow reserve
instantaneous wave‐free ratio
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 05 2022
03 05 2022
Historique:
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
6
5
2022
Statut:
ppublish
Résumé
Background The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation of Their Discrepancies) trial is a prospective registry searching for predictors of fractional flow reserve/instantaneous wave-free ratio (FFR/iFR) discrepancy. Methods and Results FFR/iFR were analyzed using a Verrata wire, and coronary flow reserve was analyzed using a Combomap machine (both Philips-Volcano). The risk polymorphisms for endothelial nitric oxide synthase and for heme oxygenase-1 were analyzed. In total, 1884 FFR/iFR measurements from 1564 patients were included. The FFR/iFR discrepancy occurred in 393 measurements (20.9%): FFRp (positive)/iFRn (negative) type (264 lesions, 14.0%) and FFRn/iFRp (129 lesions, 6.8%) type. Coronary flow reserve was measured in 343 lesions, correlating better with iFR (R=0.56,
Identifiants
pubmed: 35502771
doi: 10.1161/JAHA.121.021490
pmc: PMC9238629
doi:
Substances chimiques
Hemoglobins
0
Nitric Oxide Synthase Type III
EC 1.14.13.39
Heme Oxygenase-1
EC 1.14.14.18
Banques de données
ClinicalTrials.gov
['NCT03033810']
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e021490Investigateurs
Tomas Kovarnik
(T)
Ales Kral
(A)
Stepan Jerabek
(S)
David Zemanek
(D)
Jan Pudil
(J)
Jiri Humhal
(J)
Karel Gorican
(K)
Michael Padour
(M)
Stanislav Šimek
(S)
Jan Belohlavek
(J)
Daniel Rob
(D)
Michaela Hronova
(M)
Ales Kral
(A)
Matsuo Hitoshi
(M)
Yoshiaki Kawase
(Y)
Hiroyuki Omori
(H)
Toru Tanigaki
(T)
Alexandra Vodzinska
(A)
Jindrich Cerny
(J)
Jan Indrak
(J)
Miroslav Hudec
(M)
Marian Branny
(M)
Jan Mrozek
(J)
Martin Porzer
(M)
Tomas Grezl
(T)
Roman Stipal
(R)
Petr Kala
(P)
Jan Kanovsky
(J)
Otakar Bocek
(O)
Martin Poloczek
(M)
Petr Jerabek
(P)
Kamil Novobilsky
(K)
Tomas Kolomaznik
(T)
Oscar Mendiz
(O)
Karel Kopriva
(K)
Martin Mates
(M)
Frantisek Holy
(F)
Martin Chval
(M)
Zhi Chen
(Z)
Pavel Martasek
(P)
Lubomir Kralik
(L)
Commentaires et corrections
Type : CommentIn
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