Rational Development of Bacterial Ureases Inhibitors.
Antimicrobials
Computer-aided drug design
Ebselen
Enzyme
Phosphonates
Journal
Chemical record (New York, N.Y.)
ISSN: 1528-0691
Titre abrégé: Chem Rec
Pays: United States
ID NLM: 101085550
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
28
03
2022
received:
08
02
2022
pubmed:
4
5
2022
medline:
10
8
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
Urease, an enzyme that catalyzes the hydrolysis of urea, is a virulence factor of various pathogenic bacteria. In particular, Helicobacter pylori, that colonizes the digestive tract and Proteus spp., that can infect the urinary tract, are related to urease activity. Therefore, urease inhibitors are considered as potential therapeutics against these infections. This review describes current knowledge of the structures, activity, and biological importance of bacterial ureases. Moreover, the structure-based design of several classes of bacterial urease inhibitors is presented and discussed. Phosphinic and phosphonic acids were applied as transition-state analogues, while Michael acceptors and ebselen derivatives were applied as covalent binders of cysteine residue. This review incorporates bacterial urease inhibitors from literature published between 2008 and 2021.
Identifiants
pubmed: 35502852
doi: 10.1002/tcr.202200026
doi:
Substances chimiques
Enzyme Inhibitors
0
Urea
8W8T17847W
Urease
EC 3.5.1.5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200026Subventions
Organisme : National Science Centre, Poland
ID : 2018/31/B/NZ6/02017
Informations de copyright
© 2022 The Chemical Society of Japan & Wiley-VCH GmbH.
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