Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions.

developmental and epileptic encephalopathy electroencephalogram focal epilepsy idiopathic generalized epilepsy semiology

Journal

Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R

Informations de publication

Date de publication:
06 2022
Historique:
revised: 11 03 2022
received: 23 04 2021
accepted: 16 03 2022
pubmed: 4 5 2022
medline: 7 6 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

Epilepsy syndromes have been recognized for >50 years, as distinct electroclinical phenotypes with therapeutic and prognostic implications. Nonetheless, no formally accepted International League Against Epilepsy (ILAE) classification of epilepsy syndromes has existed. The ILAE Task Force on Nosology and Definitions was established to reach consensus regarding which entities fulfilled criteria for an epilepsy syndrome and to provide definitions for each syndrome. We defined an epilepsy syndrome as "a characteristic cluster of clinical and electroencephalographic features, often supported by specific etiological findings (structural, genetic, metabolic, immune, and infectious)." The diagnosis of a syndrome in an individual with epilepsy frequently carries prognostic and treatment implications. Syndromes often have age-dependent presentations and a range of specific comorbidities. This paper describes the guiding principles and process for syndrome identification in both children and adults, and the template of clinical data included for each syndrome. We divided syndromes into typical age at onset, and further characterized them based on seizure and epilepsy types and association with developmental and/or epileptic encephalopathy or progressive neurological deterioration. Definitions for each specific syndrome are contained within the corresponding position papers.

Identifiants

pubmed: 35503715
doi: 10.1111/epi.17237
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1333-1348

Informations de copyright

© 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

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Auteurs

Elaine C Wirrell (EC)

Divisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Rima Nabbout (R)

Reference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Sick Children Hospital, Public Hospital Network of Paris, member of EpiCARE, Paris, France.
Imagine Institute, National Institute of Health and Medical Research, Mixed Unit of Research 1163, University of Paris, Paris, France.

Ingrid E Scheffer (IE)

Austin Health and Royal Children's Hospital, Florey Institute, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.

Taoufik Alsaadi (T)

Department of Neurology, American Center for Psychiatry and Neurology, Abu Dhabi, United Arab Emirates.

Alicia Bogacz (A)

Faculty of Medicine, Clinics Hospital, Institute of Neurology, University of the Republic, Montevideo, Uruguay.

Jacqueline A French (JA)

New York University Grossman School of Medicine and NYU Langone Health, New York, New York, USA.

Edouard Hirsch (E)

Francis Rohmer Neurology Epilepsy Unit, National Institute of Health and Medical Research 1258, Federation of Translational Medicine of Strasbourg, Strasbourg University, Strasbourg, France.

Satish Jain (S)

Indian Epilepsy Center, New Delhi, India.

Sunao Kaneko (S)

North Tohoku Epilepsy Center, Minato Hospital, Hachinohe, Japan.

Kate Riney (K)

Neurosciences Unit, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Pauline Samia (P)

Department of Pediatrics and Child Health, Aga Khan University, Nairobi, Kenya.

O Carter Snead (OC)

Department Pediatrics [Neurology], Faculty of Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Ernest Somerville (E)

Prince of Wales Hospital and University of New South Wales, Sydney, New South Wales, Australia.

Nicola Specchio (N)

Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, Scientific Institute for Research and Health Care, member of EpiCARE, Rome, Italy.

Eugen Trinka (E)

Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria.
Center for Cognitive Neuroscience, member of EpiCARE, Salzburg, Austria.
Neuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria.

Sameer M Zuberi (SM)

Paediatric Neurosciences Research Group, Royal Hospital for Children and Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
Collaborating Centre of European Reference Network EpiCARE, Glasgow, UK.

Simona Balestrini (S)

Neuroscience Department, Meyer Children's Hospital-University of Florence, Florence, Italy.
Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Buckinghamshire, UK.

Samuel Wiebe (S)

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

J Helen Cross (JH)

Programme of Developmental Neurosciences, University College London National Institute for Health Research Biomedical Research Centre Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children, London, UK.
Young Epilepsy Lingfield, Lingfield, UK.

Emilio Perucca (E)

Department of Neurosciences, Monash University, Melbourne, Victoria, Australia.
Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.

Solomon L Moshé (SL)

Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology, and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.

Paolo Tinuper (P)

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Institute of Neurological Sciences, Scientific Institute for Research and Health Care, Bologna, Italy.

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