Inhibition of NAD kinase elevates the hepatic NAD

Acetaminophen / adverse effects Animals Chemical and Drug Induced Liver Injury / drug therapy Liver Mice Mice, Inbred C57BL NAD Phosphotransferases (Alcohol Group Acceptor)
Acetaminophen Acute liver injury Nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide kinase Oxidative stress

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
05 07 2022
Historique:
received: 18 03 2022
revised: 14 04 2022
accepted: 18 04 2022
pubmed: 4 5 2022
medline: 31 5 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

Acetaminophen (APAP) overdose induces acute liver injury (ALI), even acute liver failure (ALF). There is a significant unmet need to furtherly elucidate the mechanisms and find new therapeutic target. Recently, emerging evidence indicates that nicotinamide adenine dinucleotide (NAD

Identifiants

DOI: 10.1016/j.bbrc.2022.04.079 PMID: 35504092
pubmed: 35504092
pii: S0006-291X(22)00614-3
doi: 10.1016/j.bbrc.2022.04.079
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
Acetaminophen 362O9ITL9D
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
NAD kinase EC 2.7.1.23

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

70-76

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Cuiting Liao (C)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Li Zhang (L)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Rong Jiang (R)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Juanjuan Xu (J)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Jiarui Tang (J)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Kai Hu (K)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Shifang Jiang (S)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Longhui Li (L)

Center of Health Management, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400000, China.

Yongqiang Yang (Y)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Jiayi Huang (J)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Li Tang (L)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China.

Longjiang Li (L)

Department of Pathophysiology, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, China. Electronic address: 100394@cqmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Acétaminophène › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Système digestif › Foie › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Inhibition of NAD kinase elevates the hepatic NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Inhibition of NAD kinase elevates the hepatic NAD