Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.


Journal

Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615

Informations de publication

Date de publication:
06 2022
Historique:
received: 21 02 2022
accepted: 24 03 2022
pubmed: 4 5 2022
medline: 18 5 2022
entrez: 3 5 2022
Statut: ppublish

Résumé

Subsequent to the dietary uptake of nitrate/nitrite in combination with acetaldehyde/ethanol, combination effects resulting from the sustained endogenous exposure to nitrite and acetaldehyde may be expected. This may imply locoregional effects in the upper gastrointestinal tract as well as systemic effects, such as a potential influence on endogenous formation of N-nitroso compounds (NOC). Salivary concentrations of the individual components nitrate and nitrite and acetaldehyde are known to rise after ingestion, absorption and systemic distribution, thereby reflecting their respective plasma kinetics and parallel secretion through the salivary glands as well as the microbial/enzymatic metabolism in the oral cavity. Salivary excretion may also occur with certain drug molecules and food constituents and their metabolites. Therefore, putative combination effects in the oral cavity and the upper digestive tract may occur, but this has remained largely unexplored up to now. In this Guest Editorial, published evidence on exposure levels and biokinetics of nitrate/nitrite/NO

Identifiants

pubmed: 35504979
doi: 10.1007/s00204-022-03296-0
pii: 10.1007/s00204-022-03296-0
doi:

Substances chimiques

Nitrates 0
Nitrites 0
Nitroso Compounds 0
Acetaldehyde GO1N1ZPR3B

Types de publication

Editorial

Langues

eng

Sous-ensembles de citation

IM

Pagination

1905-1914

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : HE 2509/15-11

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Gerhard Eisenbrand (G)

, Kühler Grund 48/1, 69126, Heidelberg, Germany. geisenbra@gmail.com.

Matthias Baum (M)

Solenis Germany Industries GmbH, Fütingsweg 20, 47805, Krefeld, Germany.

Alexander T Cartus (AT)

Chemservice S.A., 13, Fausermillen, 6689, Mertert, Luxembourg.

Patrick Diel (P)

Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.

Karl-Heinz Engel (KH)

Chair of General Food Technology, Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354, Freising, Germany.

Barbara Engeli (B)

Risk Assessment Division, Federal Food Safety and Veterinary Office (FSVO), Schwarzenburgstrasse 155, 3003, Bern, Switzerland.

Bernd Epe (B)

Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany.

Tilman Grune (T)

Department of Molecular Toxicology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

Sabine Guth (S)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.

Dirk Haller (D)

ZIEL, Institute for Food and Health, Technical University of Munich, 85354, Freising, Germany.
Chair of Nutrition and Immunology, Technical University of Munich, Gregor-Mendel-Str. 2, 85354, Freising, Germany.

Volker Heinz (V)

German Institute of Food Technologies (DIL), Prof.-von-Klitzing-Str. 7, 49610, Quakenbrück, Germany.

Michael Hellwig (M)

Institute of Food Chemistry, Technical University of Braunschweig, Schleinitzstr. 20, 38106, Braunschweig, Germany.

Jan G Hengstler (JG)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.

Thomas Henle (T)

Department of Food Chemistry, TU Dresden, Bergstrasse 66, 01069, Dresden, Germany.

Hans-Ulrich Humpf (HU)

Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149, Münster, Germany.

Henry Jäger (H)

Institute of Food Technology, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190, Vienna, Austria.

Hans-Georg Joost (HG)

Department of Experimental Diabetology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

Sabine Kulling (S)

Department of Safety and Quality of Fruit and Vegetables, Federal Research Institute of Nutrition and Food, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.

Dirk W Lachenmeier (DW)

Chemisches und Veterinäruntersuchungsamt Karlsruhe, Weißenburger Straße 3, 76187, Karlsruhe, Germany.

Alfonso Lampen (A)

Risk Assessment Strategies, Bundesinstitut für Risikobewertung (BfR), Max-Dohrn-Straße 8-10, Berlin, Germany.

Marcel Leist (M)

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.

Angela Mally (A)

Department of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.

Doris Marko (D)

Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.

Ute Nöthlings (U)

Department of Nutrition and Food Sciences, Nutritional Epidemiology, Rheinische Friedrich-Wilhelms University Bonn, Friedrich-Hirzebruch-Allee 7, 53115, Bonn, Germany.

Elke Röhrdanz (E)

Unit Reproductive and Genetic Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175, Bonn, Germany.

Angelika Roth (A)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.

Joachim Spranger (J)

Department of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12203, Berlin, Germany.

Richard Stadler (R)

Institute of Food Safety and Analytic Sciences, Nestlé Research Centre, Route du Jorat 57, 1000, Lausanne 26, Switzerland.

Stefan Vieths (S)

Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225, Langen, Germany.

Wim Wätjen (W)

Institut für Agrar- und Ernährungswissenschaften, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 22, 06120, Halle (Saale), Germany.

Pablo Steinberg (P)

Federal Research Institute of Nutrition and Food, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany. pablo.steinberg@mri.bund.de.

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