Interleukin-4 Reduces Lesion Volume and Improves Neurological Function in the Acute Phase after Experimental Traumatic Brain Injury in Mice.

Animals Brain Injuries, Traumatic Contusions Disease Models, Animal Interleukin-4 / metabolism Mice Mice, Inbred C57BL Mice, Knockout
CCI controlled cortical impact functional outcome interleukin-4 neuroinflammation traumatic brain injury

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
09 2022
Historique:
pubmed: 5 5 2022
medline: 9 9 2022
entrez: 4 5 2022
Statut: ppublish

Résumé

Little is known about the impact of interleukin-4 (IL-4) on secondary brain damage in the acute phase after experimental traumatic brain injury (TBI). Therefore, we evaluated the effect of IL-4-Knockout (IL-4-KO) on structural damage, as well as functional impairment, in the acute phase after experimental TBI in mice. A total of 28 C57Bl/6 wildtype and 20 C57BL/6-

Identifiants

DOI: 10.1089/neu.2021.0497 PMID: 35505616
pubmed: 35505616
doi: 10.1089/neu.2021.0497
doi:

Substances chimiques

Il4 protein, mouse 0
Interleukin-4 207137-56-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1262-1272

Auteurs

Johannes Walter (J)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

Olga Kovalenko (O)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

Alexander Younsi (A)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

Martin Grutza (M)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

Andreas Unterberg (A)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

Klaus Zweckberger (K)

Department of Neurosurgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Plaies et blessures › Plaies non pénétrantes › Contusions › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Interleukin-4 Reduces Lesion Volume and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Interleukin-4 Reduces Lesion Volume and...