Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro.

Adjuvants, Immunologic BCG Vaccine Humans Infant Infant, Newborn Lipid Metabolism Tuberculosis
BCG CP: Immunology innate immunity lipidomics lysophosphatidylcholine metabolism metabolomics newborn systems vaccinology trained immunity vaccine

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
03 05 2022
Historique:
received: 01 04 2021
revised: 26 11 2021
accepted: 11 04 2022
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 7 5 2022
Statut: ppublish

Résumé

Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection and receive the most vaccines. Bacille Calmette-Guérin (BCG) protects infants against disseminated tuberculosis (TB) and TB-unrelated infections via incompletely understood mechanisms. We employ mass-spectrometry-based metabolomics of blood plasma to profile BCG-induced infant responses in Guinea-Bissau in vivo and the US in vitro. BCG-induced lysophosphatidylcholines (LPCs) correlate with both TLR-agonist- and purified protein derivative (PPD, mycobacterial antigen)-induced blood cytokine production in vitro, raising the possibility that LPCs contribute to BCG immunogenicity. Analysis of an independent newborn cohort from The Gambia demonstrates shared vaccine-induced metabolites, such as phospholipids and sphingolipids. BCG-induced changes to the plasma lipidome and LPCs may contribute to its immunogenicity and inform the development of early life vaccines.

Identifiants

DOI: 10.1016/j.celrep.2022.110772 PMID: 35508141 PMC: PMC9157458
pubmed: 35508141
pii: S2211-1247(22)00536-8
doi: 10.1016/j.celrep.2022.110772
pmc: PMC9157458
mid: NIHMS1804982
pii:
doi:

Substances chimiques

Adjuvants, Immunologic 0
BCG Vaccine 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110772

Subventions

Organisme : NHLBI NIH HHS
ID : K01 HL146980
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124284
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118608
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI168643
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests O.L. is a named inventor on several Boston Children’s Hospital patents relating to human microphysiologic assay systems and vaccine adjuvants. S.M. and G.M. are employees of Metabolon. The other authors declare no competing financial interests.

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Auteurs

Joann Diray-Arce (J)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: joann.arce@childrens.harvard.edu.

Asimenia Angelidou (A)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Kristoffer Jarlov Jensen (KJ)

Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, University of Southern Denmark, 2300 Copenhagen, Denmark; Bandim Health Project, Department of Clinical Research, University of Southern Denmark, 1455 Copenhagen K, Denmark; Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark.

Maria Giulia Conti (MG)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Maternal and Child Health, Sapienza University of Rome, 00185 Rome, Italy.

Rachel S Kelly (RS)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Matthew A Pettengill (MA)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Mark Liu (M)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.

Simon D van Haren (SD)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Scott D McCulloch (SD)

Metabolon, Morrisville, NC 27560, USA.

Greg Michelloti (G)

Metabolon, Morrisville, NC 27560, USA.

Olubukola Idoko (O)

The Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Tobias R Kollmann (TR)

Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.

Beate Kampmann (B)

The Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Hanno Steen (H)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.

Al Ozonoff (A)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.

Jessica Lasky-Su (J)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Christine S Benn (CS)

Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, University of Southern Denmark, 2300 Copenhagen, Denmark; Bandim Health Project, Department of Clinical Research, University of Southern Denmark, 1455 Copenhagen K, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, 5230 Odense M, Denmark.

Ofer Levy (O)

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins antituberculeux › Vaccin BCG › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Bacille Calmette-Guérin vaccine reprograms...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Bacille Calmette-Guérin vaccine reprograms...