The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates.
AFM-IR
amyloid
insulin
phospholipids
toxicity
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
28
04
2022
received:
15
04
2022
accepted:
29
04
2022
pubmed:
6
5
2022
medline:
16
6
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this work, we examine the effect of both saturated PS (DMPS) and unsaturated PS (DOPS and POPS) on the aggregation properties of insulin, as well as the structure and toxicity of insulin aggregates formed in the presence of these phospholipids. We found that the degree of unsaturation of fatty acids in PS alters the rate of insulin aggregation. We also found that toxicity of insulin-DMPS aggregates is significantly lower than the toxicity of DOPS- and POPS-insulin fibrils, whereas all these lipid-containing aggregates exert lower cell toxicity than insulin fibrils grown in a lipid-free environment.
Identifiants
pubmed: 35510803
doi: 10.1002/1873-3468.14369
pmc: PMC9197964
mid: NIHMS1812697
doi:
Substances chimiques
Amyloid
0
Amyloidogenic Proteins
0
Fatty Acids
0
Insulin
0
Phosphatidylserines
0
Phospholipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1424-1433Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM142869
Pays : United States
Informations de copyright
© 2022 Federation of European Biochemical Societies.
Références
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
Chem Rev. 2017 Apr 12;117(7):5146-5173
pubmed: 27958707
Ultramicroscopy. 2016 Jun;165:26-33
pubmed: 27060278
Nat Commun. 2015 Jul 28;6:7831
pubmed: 26215704
Biochem J. 1983 Apr 1;211(1):155-62
pubmed: 6870819
Chembiochem. 2020 Feb 17;21(4):481-485
pubmed: 31299124
J Chem Phys. 2018 Mar 28;148(12):123322
pubmed: 29604892
Biophys J. 2014 Jan 7;106(1):263-71
pubmed: 24411258
Indian J Endocrinol Metab. 2015 Jan-Feb;19(1):174-7
pubmed: 25593849
ACS Nano. 2020 May 26;14(5):5213-5222
pubmed: 32159944
Commun Biol. 2021 Jan 4;4(1):19
pubmed: 33398040
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003
pubmed: 25855634
J Phys Chem Lett. 2022 Mar 17;13(10):2467-2473
pubmed: 35266717
Elife. 2018 Jul 03;7:
pubmed: 29969391
BMC Endocr Disord. 2019 Jun 13;19(1):61
pubmed: 31196059
Chem Commun (Camb). 2010 Oct 14;46(38):7154-6
pubmed: 20820535
Anal Chem. 2020 May 19;92(10):6806-6810
pubmed: 32347706
Anal Chem. 2020 Aug 18;92(16):11297-11304
pubmed: 32683857
Am J Hematol. 2012 Nov;87(11):E131-2
pubmed: 23044893
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7065-70
pubmed: 27298346
Front Cell Neurosci. 2019 May 01;13:175
pubmed: 31118888
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
pubmed: 18216768
Annu Rev Phys Chem. 2011;62:279-99
pubmed: 21219138
Nat Commun. 2018 Sep 6;9(1):3609
pubmed: 30190461
Anal Chem. 2013 Feb 19;85(4):1972-9
pubmed: 23363013
Anal Chem. 2019 Feb 5;91(3):2472-2479
pubmed: 30624904
ACS Chem Neurosci. 2021 Feb 3;12(3):473-488
pubmed: 33455165
Auton Neurosci. 2016 Jan;194:46-51
pubmed: 26777075
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5835-40
pubmed: 27162352
J Biophotonics. 2012 Mar;5(3):215-9
pubmed: 22271749
J Neurochem. 1997 Oct;69(4):1746-52
pubmed: 9326304
Nat Rev Mol Cell Biol. 2018 Dec;19(12):755-773
pubmed: 30237470
Biochim Biophys Acta. 2013 Oct;1828(10):2328-38
pubmed: 23746423
Intern Med. 2010;49(5):397-401
pubmed: 20190472
J Parkinsons Dis. 2017;7(3):433-450
pubmed: 28671142
Front Neurosci. 2019 Apr 11;13:328
pubmed: 31031582
Nat Rev Mol Cell Biol. 2014 Jun;15(6):384-96
pubmed: 24854788
J Phys Chem Lett. 2021 May 13;12(18):4407-4414
pubmed: 33945282
Cell Rep. 2020 Sep 15;32(11):108132
pubmed: 32937123
ACS Nano. 2017 Dec 26;11(12):12202-12209
pubmed: 29165985
Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8519-8524
pubmed: 29749066
Nat Chem Biol. 2015 Mar;11(3):229-34
pubmed: 25643172
Front Cell Dev Biol. 2020 Sep 15;8:562241
pubmed: 33042996
Chem Soc Rev. 2020 Jun 7;49(11):3315-3347
pubmed: 32424384
Nat Commun. 2018 Sep 24;9(1):3890
pubmed: 30250131
J Am Chem Soc. 2012 Aug 15;134(32):13323-9
pubmed: 22813355
Nano Lett. 2019 Sep 11;19(9):6535-6546
pubmed: 31455083
Trends Cell Biol. 2020 May;30(5):341-353
pubmed: 32302547
Anal Chem. 2015 Mar 17;87(6):3154-9
pubmed: 25707296