Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: Results from eight European centres.

Esophageal Neoplasms / diagnostic imaging Humans Proton Therapy / methods Protons Radiotherapy Planning, Computer-Assisted / methods Radiotherapy, Intensity-Modulated / methods
Anatomical changes Intensity modulated radiotherapy Oesophageal cancer Phase III trial Proton therapy Quality assurance Respiratory motion Treatment planning

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
07 2022
Historique:
received: 09 01 2022
revised: 06 04 2022
accepted: 28 04 2022
pubmed: 6 5 2022
medline: 23 6 2022
entrez: 5 5 2022
Statut: ppublish

Résumé

To compare dose distributions and robustness in treatment plans from eight European centres in preparation for the European randomized phase-III PROTECT-trial investigating the effect of proton therapy (PT) versus photon therapy (XT) for oesophageal cancer. All centres optimized one PT and one XT nominal plan using delineated 4DCT scans for four patients receiving 50.4 Gy (RBE) in 28 fractions. Target volume receiving 95% of prescribed dose (V95% All PT and XT plans complied with V95% Large variability in dose to the lungs and heart was observed for both modalities. Inter-fractional anatomical changes led to larger target dose deterioration for XT than PT plans.

Identifiants

DOI: 10.1016/j.radonc.2022.04.029 PMID: 35513132
pubmed: 35513132
pii: S0167-8140(22)00235-3
doi: 10.1016/j.radonc.2022.04.029
pii:
doi:

Substances chimiques

Protons 0

Types de publication

Clinical Trial, Phase III Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

32-41

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Lone Hoffmann (L)

Department of Medical Physics, Aarhus University Hospital, Denmark; Dept. of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Denmark. Electronic address: Lone.Hoffmann@aarhus.rm.dk.

Hanna Mortensen (H)

Danish Center for Particle Therapy, Aarhus University Hospital, Denmark.

Muhammad Shamshad (M)

Department of Medical Physics, Aarhus University Hospital, Denmark; Dept. of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Denmark; Danish Center for Particle Therapy, Aarhus University Hospital, Denmark.

Maaike Berbee (M)

Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, The Netherlands.

Nicola Bizzocchi (N)

Center for Proton Therapy, Paul Scherrer Institut, Villigen, Switzerland.

Rebecca Bütof (R)

Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.

Richard Canters (R)

Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, The Netherlands.

Gilles Defraene (G)

KU Leuven - University of Leuven - Department of Oncology - Laboratory of Experimental Radiotherapy, Belgium.

Mai Lykkegaard Ehmsen (ML)

Danish Center for Particle Therapy, Aarhus University Hospital, Denmark.

Francesca Fiorini (F)

Rutherford Cancer Centre, Shinfield, Reading, UK.

Karin Haustermans (K)

KU Leuven - University of Leuven - Department of Oncology - Laboratory of Experimental Radiotherapy, Belgium; University Hospitals Leuven, Department of Radiation Oncology, Belgium.

Ryan Hulley (R)

Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.

Erik W Korevaar (EW)

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.

Matthew Clarke (M)

Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.

Sebastian Makocki (S)

Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.

Christina T Muijs (CT)

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.

Luke Murray (L)

Rutherford Cancer Centre, Shinfield, Reading, UK.

Owen Nicholas (O)

South West Wales Cancer Centre, Swansea University Board and Swansea University Medical School, UK.

Marianne Nordsmark (M)

Department of Oncology, Aarhus University Hospital, Denmark.

Ganesh Radhakrishna (G)

Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.

Melissa Thomas (M)

KU Leuven - University of Leuven - Department of Oncology - Laboratory of Experimental Radiotherapy, Belgium; University Hospitals Leuven, Department of Radiation Oncology, Belgium.

Esther G C Troost (EGC)

Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.

Gloria Vilches-Freixas (G)

Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, The Netherlands.

Sabine Visser (S)

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.

Damien C Weber (DC)

Center for Proton Therapy, Paul Scherrer Institut, Villigen, Switzerland; Radiation Oncology Department, University Hospital Zurich, Zurich, Switzerland.

Ditte Sloth Møller (DS)

Department of Medical Physics, Aarhus University Hospital, Denmark; Dept. of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Denmark.

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Classifications MeSH

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questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Protonthérapie › Treatment planning comparison in the...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Treatment planning comparison in the...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Thérapie assistée par ordinateur › Radiothérapie assistée par ordinateur › Planification de radiothérapie assistée par ordinateur › Treatment planning comparison in the...
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