Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
05 05 2022
05 05 2022
Historique:
received:
04
12
2020
accepted:
21
04
2022
revised:
20
04
2022
entrez:
5
5
2022
pubmed:
6
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
Children of mothers with prenatal depressive symptoms (PND) have a higher risk of behavioral problems; fetal programming through DNA methylation is a possible underlying mechanism. This study investigated DNA methylation in cord blood to identify possible "at birth" signatures that may indicate susceptibility to behavioral problems at 18 months of age. Cord blood was collected from 256 children of mothers who had self-reported on symptoms of depression during pregnancy and the behavior of their child at 18 months of age. Whole genome DNA methylation was assessed using Illumina MethylationEPIC assay. The mother and child pairs were categorized into four groups, based on both self-reported depressive symptoms, PND or Healthy control (HC), and scores from the Child Behavior checklist (high or low for internalizing, externalizing, and total scores). Adjustments were made for batch effects, cell-type, and clinical covariates. Differentially methylated sites were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p values < 0.05 were considered significant. The analysis was also stratified by sex of the child. Among boys, we observed higher and correlated DNA methylation of one CpG-site in the promoter region of TPP1 in the HC group, with high externalizing scores compared to HC with low externalizing scores. Boys in the PND group showed lower DNA methylation in NUDT15 among those with high, compared to low, internalizing scores; the DNA methylation levels of CpGs in this gene were positively correlated with the CBCL scores. Hence, the differentially methylated CpG sites could be of interest for resilience, regardless of maternal mental health during pregnancy. The findings are in a relatively healthy study cohort, thus limiting the possibility of detecting strong effects associated with behavioral difficulties. This is the first investigation of cord blood DNA methylation signs of fetal programming of PND on child behavior at 18 months of age and thus calls for independent replications.
Identifiants
pubmed: 35513368
doi: 10.1038/s41398-022-01954-6
pii: 10.1038/s41398-022-01954-6
pmc: PMC9072531
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
186Informations de copyright
© 2022. The Author(s).
Références
J Affect Disord. 2013 Apr 5;146(2):224-30
pubmed: 23116811
Epigenetics. 2008 Mar-Apr;3(2):97-106
pubmed: 18536531
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Przegl Lek. 2006;63 Suppl 1:44-7
pubmed: 17471821
Genome Med. 2020 Oct 14;12(1):88
pubmed: 33054850
J Affect Disord. 2020 Aug 1;273:542-551
pubmed: 32560952
Placenta. 2017 Oct;58:122-132
pubmed: 28962690
Lancet. 2014 Nov 15;384(9956):1800-19
pubmed: 25455250
JAMA Netw Open. 2020 Jan 03;3(1):e1919940
pubmed: 31995213
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
Transl Psychiatry. 2021 Nov 8;11(1):572
pubmed: 34750344
Epigenomics. 2012 Jun;4(3):325-41
pubmed: 22690668
Clin Epigenetics. 2021 Apr 12;13(1):78
pubmed: 33845866
Epigenetics. 2012 Jul;7(7):735-46
pubmed: 22677950
Diabetes. 2013 Apr;62(4):1320-8
pubmed: 23209187
Placenta. 2016 Apr;40:60-6
pubmed: 27016784
Nature. 1998 May 14;393(6681):187-91
pubmed: 9603525
Am J Obstet Gynecol. 2014 Nov;211(5):502.e1-8
pubmed: 24996659
BMJ Open. 2019 Oct 22;9(10):e031514
pubmed: 31641004
Oncotarget. 2017 Jan 17;8(3):3969-3979
pubmed: 27992373
Dialogues Clin Neurosci. 2005;7(2):103-23
pubmed: 16262207
Scand J Public Health. 2016 Feb;44(1):98-105
pubmed: 26459495
Genet Epigenet. 2014 Sep 14;6:37-44
pubmed: 25512713
Dev Psychopathol. 2018 Aug;30(3):843-854
pubmed: 30068411
Obstet Med. 2020 Jun;13(2):55-61
pubmed: 32714436
Transl Psychiatry. 2018 Nov 7;8(1):244
pubmed: 30405117
Genome Med. 2020 Mar 2;12(1):25
pubmed: 32114984
PLoS One. 2010 Aug 16;5(8):e12201
pubmed: 20808944
Genome Biol. 2012 Jun 15;13(6):R43
pubmed: 22703893
Neuropsychopharmacology. 2013 Jan;38(1):23-38
pubmed: 22781841
J Child Psychol Psychiatry. 2018 Apr;59(4):303-322
pubmed: 28736860
Front Immunol. 2021 Apr 12;12:617592
pubmed: 33912153
Mol Cell. 2015 Jun 4;58(5):755-66
pubmed: 25959397
Epigenetics. 2016 May 3;11(5):354-62
pubmed: 27019159
Clin Epigenetics. 2017 Aug 2;9:77
pubmed: 28785368
J Child Psychol Psychiatry. 2015 Oct;56(10):1092-100
pubmed: 25665134
Transl Psychiatry. 2015 Feb 17;5:e508
pubmed: 25689569
J Biol Chem. 2009 Feb 6;284(6):3976-84
pubmed: 19038966
Transl Psychiatry. 2019 Jan 31;9(1):47
pubmed: 30705257
Nat Neurosci. 2004 Aug;7(8):847-54
pubmed: 15220929
Dev Psychopathol. 2012 Nov;24(4):1361-76
pubmed: 23062303
Clin Child Fam Psychol Rev. 2011 Mar;14(1):1-27
pubmed: 21052833
Clin Epigenetics. 2019 Mar 29;11(1):56
pubmed: 30925934
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
J Affect Disord. 2017 Sep;219:86-92
pubmed: 28531848
J Biol Chem. 2009 Jul 17;284(29):19310-20
pubmed: 19419956
Hypertension. 2019 Aug;74(2):375-383
pubmed: 31230546
J Affect Disord. 2019 Feb 15;245:716-723
pubmed: 30447571
Epigenetics. 2016 Sep;11(9):690-698
pubmed: 27494297
BMC Genomics. 2015 Nov 09;16:911
pubmed: 26553366
F1000Res. 2016 Jun 08;5:1281
pubmed: 27347385
Genome Biol. 2014 Dec 03;15(12):503
pubmed: 25599564
Womens Health (Lond). 2012 Nov;8(6):659-72
pubmed: 23181531
Child Dev. 2016 Jan-Feb;87(1):86-97
pubmed: 26822445
Child Adolesc Psychiatry Ment Health. 2016 May 19;10:10
pubmed: 27200107
Bioinformatics. 2017 Feb 15;33(4):558-560
pubmed: 28035024
Clin Epigenetics. 2019 Oct 11;11(1):139
pubmed: 31601260
Curr Psychiatry Rep. 2019 Feb 7;21(2):7
pubmed: 30729361